Results 111 to 120 of about 2,056,194 (301)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Identification of carboxypeptidase substrates by C-terminal COFRADIC

, 2017
We here present a detailed procedure for studying protein C-termini and their posttranslational modifications by C-terminal COFRADIC. In fact, this procedure can enrich for both C-terminal and N-terminal peptides through a combination of a strong cation ...
Tanco, SebastianUGent000160192668802001601142979385849736297F72C2-FBBF-11E2-860A-B75A10BDE39D, Van Damme, Petra, Francesc Xavier Aviles, Sebastian Tanco, Kris Gevaert, Aviles, Francesc Xavier, Tanco, Sebastian, Schilling, Olivereditor, Lorenzo, Julia, Gevaert, Kris, Van Damme, PetraWE100019962028108010016113680000-0001-9090-027XF663B510-F0ED-11E1-A9DE-61C894A0A6B4, Julia Lorenzo, Petra Van Damme, Gevaert, KrisGE318010010241160000-0002-4237-0283F4EC703C-F0ED-11E1-A9DE-61C894A0A6B4   +13 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Analyzing Passenger Flows in an Airport Terminal: A Discrete Simulation Model

Computation
This paper introduces a simulation model designed as a decision-making tool to assess and analyze various crowd management strategies with a focus on enhancing sustainability in airport operations.
Cristina Oprea, Mircea Rosca, Eugen Rosca, Ilona Costea, Anamaria Ilie, Oana Dinu, Aura Ruscă   +6 more
doaj   +1 more source

Intermodal freight terminals : terminal business planning [PDF]

, 2000
The main purpose of this paper is to provide a framework for existing- and newly proposedinter-modal freight terminals in their business planning process. This framework is importantfor constructing- and improving the central terminal service portfolio of handling (loading,discharging, and transhipping) and storage of containerised cargo.
Wiegmans, Bart W., Nijkamp, Peter
openaire   +3 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Memo re: Fort Worth Air Terminal, Inc.

, 1953
Memo regarding the funding, contracts, construction and operational costs of the Fort Worth Air Terminal ...
Fort Worth Air Terminal, Inc.
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

High-Precision Calibration Technology and Experimental Verification for Dual-Axis Laser Communication Systems

Sensors
With the continuous improvement of remote sensing satellite resolution, laser communication technology has gained significant traction. The pointing accuracy of ground-based laser communication terminals is critical for the stability of satellite–ground ...
Wenyan Li, Xiaolei Zhang, Lei Zhang, Xiang Wei, Guoxi Luo, Peng Zhang, Zhipeng Xue   +6 more
doaj   +1 more source

The action is at the terminal

The Journal of Physiology, 1999
The magnocellular neurons of the supraoptic nucleus have been intensively studied because of their unique bursting and phasic activity patterns. While these can be explained in part by intrinsic membrane conductances, it is now also apparent that afferent inputs are important in sculpting and initiating the activity patterns. Modulation of these inputs,
openaire   +3 more sources