Results 101 to 110 of about 6,331,311 (408)

End-of-Life Delirium: Issues Regarding Recognition, Optimal Management and the Role of Sedation in the Dying Phase. [PDF]

, 2014
CONTEXT: In end-of-life care, delirium is often not recognized and poses unique management challenges, especially in the case of refractory delirium in the terminal phase.
Agar, M, Bruera, E, Bush, S H, Currow, D C, Hosie, Annmarie, Lawlor, P G, Leonard, M M, Meagher, D J, Spiller, J A, Wright, D   +9 more
core   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Pharmacological Treatment for Terminal Agitation, Delirium and Anxiety in Frail Older Patients

Geriatrics
Context: Psychological distress symptoms in the last days of life often contribute to the overall symptom burden in frail older patients. Good symptom management practices are crucial to ensure high-quality end-of-life care in an aging population, though
Dine A. D. Jennes, Tim Biesbrouck, Maaike L. De Roo, Tinne Smets, Nele Van Den Noortgate   +4 more
doaj   +1 more source

Attitudes toward end-of-life concerns and associated factors among hospitalized older adults with end-stage cancer in Iran [PDF]

Nursing and Midwifery Studies
Background: Nurses play a crucial role in delivering end-of-life care; however, patients' attitudes significantly influence the care process. Positive attitudes facilitate patient engagement and understanding of end-of-life options, while negative ...
Salman Rahnama, Mohammad Sajjad Lotfi, Maryam Asadi, Zahra Rezaei-Shahsavarloo   +3 more
doaj   +1 more source

On age-specific selection and extensive lifespan beyond menopause [PDF]

arXiv, 2019
Extensive post reproductive lifespan (PRLS) is observed only in a few species, such as humans or resident killer whales, and its origin is under debate. Hypotheses like mother-care and grandmother-care invoke strategies of investment--provision to one's descendants to enhance one's overall reproductive success--to explain PRLS.
arxiv  

Factors influencing palliative care in advanced dementia : A systematic review [PDF]

, 2019
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.Background: Dementia is a progressive neurodegenerative life-limiting disease.
Aslanpour, Zoe, Mataqi, Mona
core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Terminal Care and the Value of Life Near its End

, 2010
Medical care at the end of life, estimated to contribute up to a quarter of US health care spending, often encounters skepticism from payers and policy makers who question its high cost and often minimal health benefits.
Tomas Philipson, Gary S. Becker, Dana P. Goldman, Kevin M. Murphy   +3 more
semanticscholar   +1 more source

A Semiparametric Joint Model for Terminal Trend of Quality of Life and Survival in Palliative Care Research [PDF]

arXiv, 2016
Palliative medicine is an interdisciplinary specialty focusing on improving quality of life (QOL) for patients with serious illness and their families. Palliative care programs are available or under development at over 80% of large US hospitals (300+ beds).
arxiv  

Asymmetric Two-Terminal Graphene Detector for Broadband Radiofrequency Heterodyne- and Self-Mixing [PDF]

, 2018
Graphene, a single atomic layer of covalently bonded carbon atoms, has been investigated intensively for optoelectronics and represents a promising candidate for high-speed electronics. Here we present a microwave mixer constructed as an asymmetrically-contacted two-terminal graphene device based on the thermoelectric effect.
arxiv   +1 more source