Results 81 to 90 of about 5,211,884 (256)
Medicina U.P.B., 2018 Objetivo: en pediatría, los pacientes susceptibles de recibir cuidados paliativos pueden tener una supervivencia larga pero una vida limitada o amenazada por la enfermedad que padecen, por lo tanto, no solo es importante conocer las causas de muerte sino
Mussatye Elorza Parra +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Basic characteristics of terminal patients receiving traditional care or hospice carea.
, 2020 Basic characteristics of terminal patients receiving traditional care or hospice carea.
Ya-Ting Huang (3804985) +6 more
core +1 more source
Evaluation of a hospice rapid response community service: a controlled evaluation [PDF]
, 2012 (provisional) Background While most people faced with a terminal illness would prefer to die at home, less than a third in England are enabled to do so with many dying in National Health Service hospitals.
Holdsworth, LM +15 more
core +2 more sources
Critique of the Peaceful End-of-Life Theory Using Meleis’ 2012 Approach
Iranian Journal of Nursing and Midwifery ResearchBackground: Providing a peaceful end of life while preserving dignity is a fundamental goal of nursing care. The Peaceful End-of-Life Theory (PELT) offers a middle-range theoretical framework to guide holistic nursing care for terminally ill patients ...
Maryam Papi +2 more
doaj +1 more source
Paediatric trainees and end-of-life care: a needs assessment for a formal educational intervention
Perspectives on Medical Education, 2015 Background Literature suggests a paucity of formal training in end-of-life care in contemporary American medical education. Similar to trainees in adult medicine, paediatric trainees are frequently involved in end-of-life cases.
Bonnie H Arzuaga, Leslie Caldarelli
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source