Results 71 to 80 of about 5,027,395 (296)

To Do List [PDF]

, 2001
Listings from Terminal City Magazine including LIVE Biennial.

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Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Temporal Trends in Mortality Location Among Patients With Intrahepatic Cholangiocarcinoma in the USA: A Retrospective Observational Analysis of National Center for Health Statistics Mortality Data

JGH Open
Objectives Intrahepatic cholangiocarcinoma (ICC) is a malignancy with rising incidence and mortality in the United States. This study aimed to investigate temporal trends in the place of death among patients with ICC and assess demographic disparities ...
Muhammad Ahmad Nadeem, Abdullah Khan, Ahsan Raza Raja, Usama Hussain Kamal, Abdul Rafeh Awan, Jibran Ikram, Asad Ullah, Marjan Khan, Abu Baker Sheikh, Amir Humza Sohail   +9 more
doaj   +1 more source

Benefits and Harms of Antibiotic Use in End-of-Life Patients: Retrospective Study in Palliative Care

Antibiotics
Context: Many patients at the end of life receive antibiotics to alleviate symptoms and improve quality of life; however, clear guidelines supporting decision making about the use of antibiotics are still lacking. Objectives: This study aimed to evaluate
Rita Faustino Silva, Joana Brandão Silva, António Pereira Neves, Daniel Canelas, João Rocha Neves, José Paulo Andrade, Marília Dourado, Hugo Ribeiro   +7 more
doaj   +1 more source

Características epidemiológicas, clínicas y evolutivas de los pacientes pediátricos con enfermedades crónicas y limitantes, susceptibles de recibir atención por cuidados paliativos en el Hospital Pablo Tobón Uribe, Medellín, Colombia

Medicina U.P.B., 2018
Objetivo: en pediatría, los pacientes susceptibles de recibir cuidados paliativos pueden tener una supervivencia larga pero una vida limitada o amenazada por la enfermedad que padecen, por lo tanto, no solo es importante conocer las causas de muerte sino
Mussatye Elorza Parra, Alberto García-Salido, César Vanegas Díaz, Mauricio Fernández Laverde   +3 more
doaj   +1 more source

Fondation de Creis-Terminal

, 2018
La nouvelle association Creis-Terminal, fusion du Creis et de l’association éditant la revue Terminal a finalement vu le jour le 11 décembre 2009. Le principe du rapprochement entre les deux associations étaient acquis depuis la dernière assemblée ...
Vétois, Jacques
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Calendar Listings [PDF]

, 2005
Terminal City Weekly's Calendar listings including Astrid Hadad's performance.

core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source