Results 51 to 60 of about 2,509 (208)

Erratum: ‘I am afraid the news is not good’ – Breaking bad news in the time of COVID: Experiences from a field hospital

African Journal of Primary Health Care & Family Medicine
No abstract available.
Charmaine Cunningham, Pat Mayers, Janet Giddy, Magdaleen de Swardt, Peter Hodkinson   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Temporal Trends in Mortality Location Among Patients With Intrahepatic Cholangiocarcinoma in the USA: A Retrospective Observational Analysis of National Center for Health Statistics Mortality Data

JGH Open
Objectives Intrahepatic cholangiocarcinoma (ICC) is a malignancy with rising incidence and mortality in the United States. This study aimed to investigate temporal trends in the place of death among patients with ICC and assess demographic disparities ...
Muhammad Ahmad Nadeem, Abdullah Khan, Ahsan Raza Raja, Usama Hussain Kamal, Abdul Rafeh Awan, Jibran Ikram, Asad Ullah, Marjan Khan, Abu Baker Sheikh, Amir Humza Sohail   +9 more
doaj   +1 more source

Benefits and Harms of Antibiotic Use in End-of-Life Patients: Retrospective Study in Palliative Care

Antibiotics
Context: Many patients at the end of life receive antibiotics to alleviate symptoms and improve quality of life; however, clear guidelines supporting decision making about the use of antibiotics are still lacking. Objectives: This study aimed to evaluate
Rita Faustino Silva, Joana Brandão Silva, António Pereira Neves, Daniel Canelas, João Rocha Neves, José Paulo Andrade, Marília Dourado, Hugo Ribeiro   +7 more
doaj   +1 more source

Trends in End-of-Life Resource Utilization and Costs among Prostate Cancer Patients from 2006 to 2015: A Nationwide Population-Based Study

The World Journal of Men's Health, 2021
Purpose: The purpose of this study was to evaluate end-of-life resource utilization and costs for prostate cancer patients during the last year of life in Korea.
Yun-Sok Ha, So-Young Kim, Jae Il Chung, Hoon Choi, Jae Heon Kim, Ho Song Yu, In-Chang Cho, Hyung Joon Kim, Hyun Chul Chung, Jun Sung Koh, Ji Youl Lee, Dong Jin Park, Hyun Tae Kim, Eun Sang Yoo, Tae Gyun Kwon, Kyungchan Min, Wun-Jae Kim, Seok Joong Yun, Jong-Hyock Park   +18 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Analysis of differences in death anxiety and preferences for care near the end of life scale according to age of elderly nursing hospital

Nursing and Healthcare Science
Purpose: This study aims to identify age-related differences in death anxiety and Preferences for Care Near the End of Life among elderly patients in long-term care hospitals, focusing on variations as length of stay increases.
Ji Hun Joung
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Status quo and related factors analysis of cognition and attitude toward death with dignity in patients with advanced cancer

Huli yanjiu, 2020
ObjectiveTo understand the cognition and attitude toward death with dignity in patients with advanced cancer，and to analyze the influencing factors.MethodsA total of 177 patients with advanced cancer，who were in hospital in Tianjin Medical University ...
QUAN Manman, ZHANG Xiuxiu, ZHANG Jie, GUO Xin   +3 more
doaj