Results 51 to 60 of about 1,012,185 (295)

Palliative Care in Advanced Dementia

Frontiers in Psychiatry, 2020
Dementia syndrome is common and expected to increase significantly among older people and characterized by the loss of cognitive, psychological and physical functions.
Yvonne Eisenmann, Heidrun Golla, Holger Schmidt, Raymond Voltz, Raymond Voltz, Raymond Voltz, Raymond Voltz, Klaus Maria Perrar   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Care Program Based on Watson's Theory of Human Caring and its Effect on Death Anxiety and Hope for Life in Cancer Patients: A Randomized Clinical Trial [PDF]

Journal of Evidence-Based Care
Background: Cancers are the second leading cause of death worldwide, adversely affecting patients' well-being including hope for life, and cause death anxiety.Aim: This study was conducted with aim to investigate the effect of a nursing care program ...
Razieh Nikbakht, Mahdieh Poodineh Moghadam, Hossein Shahdadi, Somayeh Bagheri, Mozhgan Rahnama   +4 more
doaj   +1 more source

Prediction of survival probabilities with Bayesian Decision Trees [PDF]

, 2013
Practitioners use Trauma and Injury Severity Score (TRISS) models for predicting the survival probability of an injured patient. The accuracy of TRISS predictions is acceptable for patients with up to three typical injuries, but unacceptable for patients
Bailey, Becalick, Bishop, Bouamra, Boyd, Breiman, Chawda, Chipman, Chipman, Clermont, Denison, Dietterich, DiRusso, Domingos, Duda, Green, Hadfield, Hall, Hilden, Hunter, Jaimes, Jakaite, Kilgo, Kilgo, Koshy, Kreke, Krzanowski, Kuncheva, Li, Livia Jakaite, Lunn, Millham, Oakland, Osler, Osler, Patil, Quinlan, Robert, Rogers, Rogers, Schetinin, Schetinin, Schetinin, Schetinin, Silva, Steyerberg, Stojadinovic, Sujin, Vapnik, Vitaly Schetinin, Wojtek J. Krzanowski   +50 more
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The Value of Life Near its End and Terminal Care [PDF]

Medical care at the end of life, which is often is estimated to contribute up to a quarter of US health care spending, often encounters skepticism from payers and policy makers who question its high cost and often minimal health benefits.
Gary Becker, Kevin Murphy, Tomas Philipson   +2 more
core   +3 more sources