Results 41 to 50 of about 436,254 (306)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Terminal and palliative care [PDF]

open access: yes, 2004
Throughout the world the nature of illness is changing. People live to older ages and die later in life following chronic or progressive, rather than acute, illness. Thus palliative and terminal care are of increasing significance.
P. EDMONDS   +4 more
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Involvement of the family physician in palliative care : an outcome analysis [PDF]

open access: yes, 2004
Includes bibliographical references (leaves 60-63).An evaluation of the degree of involvement of family physicians in the care of patients with terminal illness was conducted. The outcome of this care was correlated with the degree of involvement.
Barnard, Alan J
core  

General practice service use at the end-of-life before and during the COVID-19 pandemic: a population-based cohort study using primary care electronic health records

open access: yesBJGP Open
Background: Globally, the COVID-19 pandemic has caused unprecedented strain in healthcare systems, but little is known about how it affected patients requiring palliative and end-of-life care from GPs.
Emeka Chukwusa   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Palliative Care: knowledge and feelings of the nurse working in internal medicine and infectious and contagious diseases units of a general hospital: a qualitative study

open access: yesOnline Brazilian Journal of Nursing, 2008
This study originated from the author’s concern about providing care to patients at life’s end, as she observed that this care was not approached in a holistic manner.
Marina Borges Teixeira   +1 more
doaj  

Comparison of factors influencing the decision to withdraw life-sustaining treatment in intensive care unit patients after implementation of the Life-Sustaining Treatment Act in Korea [PDF]

open access: yesAcute and Critical Care
Background The decision to discontinue intensive care unit (ICU) treatment during the end-of-life stage has recently become a significant concern in Korea, with an observed increase in life-sustaining treatment (LST) withdrawal. There is a growing demand
Claire Junga Kim   +3 more
doaj   +1 more source

The meaning of life according to patients with advanced lung cancer: a qualitative study

open access: yesInternational Journal of Qualitative Studies on Health & Well-Being, 2022
Purpose This qualitative study explores the meaning of life and end-of-life coping strategies among patients in China with advanced lung cancer. Methods We conducted in-depth interviews with 21 hospitalized patients with advanced lung cancer and analysed
Jin Mei Zhang   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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