Results 101 to 110 of about 725,409 (217)

Harmonizing TUNEL with multiplexed iterative immunofluorescence enriches spatial contextualization of cell death

Cell Reports: Methods
Summary: Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) is an essential tool for detecting cell death in tissues, but its compatibility with spatial proteomic methods is unknown.
Marc S. Sherman, Thomas McMahon-Skates, Lindsey S. Gaston, Sonya W. Katzen, Joseph A. Majzoub, Wolfram Goessling   +5 more
doaj   +1 more source

Biotinylation of Deoxyguanosine at the Abasic Site in Double-Stranded Oligodeoxynucleotides

Journal of Analytical Methods in Chemistry, 2016
Biotinylation of deoxyguanosine at an abasic site in double-stranded oligodeoxynucleotides was studied. The biotinylation of deoxyguanosine is achieved by copper-catalyzed click reaction after the conjugation of the oligodeoxynucleotide with 2-oxohex-5 ...
Chun Wu
doaj   +1 more source

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

Sensitive detection of alkaline phosphatase based on terminal deoxynucleotidyl transferase and endonuclease IV-assisted exponential signal amplification. [PDF]

J Pharm Anal, 2022
Ye W, Li L, Feng Z, Tu B, Hu Z, Xiao X, Wu T.   +6 more
europepmc   +1 more source

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source

Artemisinin alleviates hippocampal neuronal apoptosis and cognitive impairment in rats after cardiac arrest resuscitation: Association with the PI3K/Akt pathway

Pakistan Journal of Pharmaceutical Sciences
Background: Cardiac arrest (CA) is associated with high mortality and severe neurological sequelae. Artemisinin (ARS), a natural product from Artemisia annua, has potential neuroprotective effects, but its role in brain injury after CA resuscitation ...
Yuanyuan Gao, Shuwen Han, Yaojun Lu, Junli Zhao   +3 more
doaj   +1 more source

Sequence Preference and Initiator Promiscuity for <i>De Novo</i> DNA Synthesis by Terminal Deoxynucleotidyl Transferase. [PDF]

ACS Synth Biol, 2021
Schaudy E, Lietard J, Somoza MM.
europepmc   +1 more source

Occurrence of a Terminal Deoxynucleotidyl Transferase-Like Activity in N-2-Fluorenylacetamide-treated Rat Liver

A new enzyme activity that resembles terminal deoxynucleotidyl transferase (TdT-like activity) was found in rat liver. Upon treatment of rats with a hepatocarcinogen, N-2-fluorenylacetamide, the TdT-like activity increased in parallel with DNA polymerase
KOJIMA, KIYOHIDE, YOSHIDA, SHONEN, NAKAMURA, HIROMU   +2 more
core  

Shortened Protocol for Terminal Deoxynucleotidyl Transferase-Dependent PCR

BioTechniques, 2000
Neil P. Davies, Vincent Murray
doaj   +1 more source

Safety evaluation of poly(lactic-co-glycolic acid)/poly(lactic-acid) microspheres through intravitreal injection in rabbits

International Journal of Nanomedicine, 2014
Xianfang Rong,1 Weien Yuan,2 Yi Lu,1 Xiaofen Mo11Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China; 2School of Pharmacy, Shanghai Jiao Tong ...
Rong XF, Yuan WE, Lu Y, Mo XF
doaj