Results 161 to 170 of about 148,309 (199)

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Gene conversion and duplication contribute to genetic variation in an outbreak of <i>Mycobacterium tuberculosis</i>. [PDF]

Microb Genom
Stritt C, Reitsma M, Marin AMG, Goig G, Dötsch A, Borrell S, Beisel C, Comas I, Brites D, Gagneux S.   +9 more
europepmc   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

A comprehensive toolkit for protein localization and functional analysis in trypanosomatids. [PDF]

Open Biol
Paterou A, Sáez Conde J, Týč J, Sunter JD, Vaughan S, Gull K, Dean S.   +6 more
europepmc   +1 more source

Assessment and Comparative Study of Free and Commercial Numerical Software Packages for Lithium‐Ion Battery Modeling

Advanced Theory and Simulations, EarlyView.
This study evaluates the simulation capabilities of lithium‐ion battery (LIB) electrochemical simulation software packages. The benchmark simulation results reveal the impacts of parameter sensitivity to solver performance and stability. The guidelines to troubleshooting common solver failures at high current rates lowers the steep learning curve to ...
Kenneth C. Nwanoro, Michael P. Mercer, Harry E. Hoster   +2 more
wiley   +1 more source

Haplotype-resolved and gap-free genome of a floating aquatic plant from the Oryzeae tribe, Hygroryza aristata. [PDF]

BMC Genom Data
Yang LY, Huang LK, Lin JB, Xu CJ, Tang WQ, Huang BG.   +5 more
europepmc   +1 more source

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

Advanced Science, EarlyView.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen   +7 more
wiley   +1 more source

Haplotype resolved chromosome-level genome assembly of the gold barb (Barbodes semifasciolatus). [PDF]

Sci Data
Chen W, Li C, Yang R, Li Y, Wu B, Li J.
europepmc   +1 more source

Accelerated Bone Healing via Electrical Stimulation

Advanced Science, EarlyView.
Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun, Wenqing Xie, Yuxiang Wu, Zhou Li, Yusheng Li   +4 more
wiley   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases. [PDF]

FEBS Lett
Pilcher C, Buco PAV, Truong JQ, Ramsland PA, Smeets MF, Walkley CR, Holien JK.   +6 more
europepmc   +1 more source