Results 261 to 270 of about 103,119 (342)

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek‐key motif in which extensive hydrogen bonding and packing interactions formed by residues in conserved imperfect repeats stabilize a β‐solenoid core.
Samuel Peña‐Díaz   +12 more
wiley   +1 more source

Light Up a Nanocluster

open access: yesAggregate, Volume 7, Issue 1, January 2026.
Atomically precise metal nanoclusters are ultrasmall aggregates of metal atoms with finely tunable structures. They exhibit broad PL across visible to NIR wavelengths by tuning size, structure, and composition. The review addresses fundamental emission mechanisms and structure–property correlations, evaluating enhancement strategies (ligand ...
Xiuling Guo   +4 more
wiley   +1 more source

Selection maintains floral color polymorphism in scarlet paintbrush, Castilleja coccinea, reflecting combined ecological factors

open access: yesAmerican Journal of Botany, Volume 113, Issue 1, January 2026.
Abstract Premise Evolutionary theory predicts polymorphism should be rare; however, intraspecific variation in floral color is common and can be attributed to genetic drift, plasticity, or variable selection. Examining floral color polymorphism both within contact zones and across a species' range can reveal the mechanisms maintaining this variation ...
Emma Fetterly   +6 more
wiley   +1 more source

Evaluation of ASC as a therapeutic target for Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis‐associated speck‐like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation
W. Brent Clayton   +12 more
wiley   +1 more source

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei   +11 more
wiley   +1 more source

Resistance to doxorubicin-induced proteinuria and proteolytic activation of ENaC in 129S2/SvPas mice. [PDF]

open access: yesPhysiol Rep
Ray EC   +7 more
europepmc   +1 more source

Seamless and Highly Efficient Site‐directed Mutagenesis for Protein, RNA, and Plasmid Engineering

open access: yesCurrent Protocols, Volume 6, Issue 1, January 2026.
Abstract Site‐directed mutagenesis is indispensable for protein, RNA, and plasmid engineering. It is ideal to carry out such mutagenesis at an efficiency close to 100%, but many current methods fail to reach this goal and thus require extensive screening efforts.
Xiang‐Jiao Yang
wiley   +1 more source

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