Results 41 to 50 of about 806,046 (260)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

USERS’ SATISFACTION WITH INTERCITY BUS TERMINAL QUALITY IN LAGOS STATE, NIGERIA [PDF]

Scientific Journal of Silesian University of Technology. Series Transport
Globally, efficient intercity public transport relies on well-designed and high-quality terminal facilities and services to enhance accessibility, mobility, and safety for passengers and freight.
Umar Obafemi SALISU, Mubarak Olabanji GAFAR, Ayobami Ademola AKANMU, Sekinat Motunrayo SANNI, Simeon Oluwagbenga FASINA   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cigarette market state monitoring based on retail terminal data governance

Yancao ke-ji
A set of monitoring methods for domestic cigarette market state based on retail terminal data governance was proposed to address the common problems of uneven quality, distorted QR code data and false inventory reporting in cigarette retail terminal data,
Siming Jiang, Rong Liu, Shengda Tan, Hangyu Guo, Jinzhi Xu, Hong Xie, Yingjia Cai, Qi Huang   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Band engineering and phonon softening enable the achievement of significant enhancement in the thermoelectric performance of EuMg2Sb2 by Zn doping

Journal of Materiomics
The Zintl compound EuMg2Sb2 is a promising thermoelectric material due to its inherently low lattice thermal conductivity and tunable electronic and thermal properties related to its multi-component nature.
Qingzhi Song, Linyu Bai, Xi Gao, Lei Wei, Xian Zhao, Yanlu Li   +5 more
doaj   +1 more source

A Compound Controller Design for a Buck Converter

Energies, 2018
In order to improve the performance of the closed-loop Buck converter control system, a compound control scheme based on nonlinear disturbance observer (DO) and nonsingular terminal sliding mode (TSM) was developed to control the Buck converter.
Yueping Sun, Li Ma, Dean Zhao, Shihong Ding   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source