Results 31 to 40 of about 842,336 (266)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Predictive Value of Terminal QRS Distortion in Anterior Wall Acute Myocardial Infarction

open access: yesMajalah Kardiologi Indonesia, 2013
Background. The initial ECG at patients with Acute Coronary Syndrome, especially STEMI can predict size of infarction, response to reperfusion therapy and long term prognosis.
Budhi Setianto, Nur Haryono
doaj   +1 more source

Design Voltage Regulator for Synchronous Generator [PDF]

open access: yesEngineering and Technology Journal, 2008
As the loud on an alternator is varied, its terminal voltage is also found tovary. This variation terminal voltage is due to voltage drop in armature(resistance, leakage reactance) and armature reaction, therefore thisresearch aim to design voltage ...
Rifaat A. Jaafar   +3 more
doaj   +1 more source

Value of Information in the Deterministic Optimal Resource Extraction Problem with Terminal Constraints

open access: yesApplied Sciences, 2023
In this paper, we consider a continuous-time differential game of non-renewable resource extraction with n players and assume that the terminal conditions of the game vary. To characterize the gain that the players obtain by using precise information, we
Ekaterina Gromova, Aisana Bolatbek
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Unravelling the impact of consumer personal value on word of mouth in Indonesia's Islamic higher education: The mediating role of emotional attachment

open access: yesSustainable Futures
Word-of-mouth (WOM) plays a critical role in student recruitment within Indonesia’s Islamic Higher Education (IHE), which operates in unique socio-cultural and religious contexts.
Ahmad Juhaidi   +2 more
doaj   +1 more source

Modeling of Sapodilla Fruit (Manilkara zapota (L.) van Royen) Terminal Velocity in Water

open access: yesRona Teknik Pertanian, 2018
. Terminal velocity is one of the hydrodynamic fruits properties that significant in the development of sorting equipment. The study aimed to determine terminal velocity of sapodilla which could be used while develop a sorter.
Andasuryani Andasuryani, Renny Eka Putri
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

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