Results 51 to 60 of about 1,825,154 (302)
Journal of Pharmacy & Pharmaceutical Sciences, 2014 The pharmacokinetics of clozapine is a subject of intensive research because of its narrow therapeutic window and susceptibility to drug-drug interactions.
Jim Fang, Karen Mosier
doaj +1 more source
Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases
Life Science Alliance, 2023 The design of a constitutively active form of the C-terminal kinase domain of the p90 ribosomal S6 kinase 2 (RSK2) is described, and this is based on a phosphomimetic mutation and a C-terminal truncation, yielding a high kinase activity.
Marlene Uglebjerg Fruergaard +5 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Global search algorithm for optimal control [PDF]
, 1970 Random-search algorithm employs local and global properties to solve two-point boundary value problem in Pontryagin maximum principle for either fixed or variable end-time problems. Mixed boundary value problem is transformed to an initial value problem.
Brocker, D. H. +2 more
core +1 more source
Enhanced photon-assisted spin transport in a quantum dot attached to ferromagnetic leads
, 2011 We investigate real-time dynamics of spin-polarized current in a quantum dot coupled to ferromagnetic leads in both parallel and antiparallel alignments.
Carrara, Thiago L. +2 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Frontiers in SleepPersonal values shape health behaviors, yet the role of sleep value within broader value systems remains unknown. This study aimed to validate the Values Inventory, a novel measure assessing individual life values, and examine how sleep value fits into ...
Dustin Sherriff +6 more
doaj +1 more source
DYNAMICS OF VITAL VALUES OF ADOLESCENTS AND A PROBLEM OF CORRUPTION IN POST-SOVIET RUSSIA
Образование и наука, 2016 The purpose of the article is to show immanent interrelation between structure of terminal and tool vital values of adolescents of the Post-Soviet period and predisposition to perpetrate of corruption actions. Methods.
Pyotr N. Kondrashov
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The Pattern Speed of the Galactic Bar [PDF]
, 1999 Most late-type stars in the solar neighborhood have velocities similar to the local standard of rest (LSR), but there is a clearly separated secondary component corresponding to a slower rotation and a mean outward motion.
Asian R. +11 more
core +3 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source