Results 251 to 260 of about 1,667,342 (377)

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Expected benefits and concerns regarding virtual reality in caring for terminally ill cancer patients - a qualitative interview study. [PDF]

BMC Palliat Care
Greinacher A, Alt-Epping B, Gerlach C, Wrzus C.   +3 more
europepmc   +1 more source

[Book Review of] \u3cem\u3eLast Wish\u3c/em\u3e, by Betty Rollin [PDF]

, 1986
Barry, Robert
core   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Exploring the Role of Practical and Emotional Death Preparation in Reducing Emotional Distress Among Family Caregivers of Terminally Ill Cancer Patients: A Multicenter Cross-Sectional Study. [PDF]

Cancers (Basel)
Kim B, Kim J, Ahn HY, Park S, Hwang IC, Park SJ.   +5 more
europepmc   +1 more source

Determinants of Preference for Home Death Among Terminally Ill Patients With Cancer in Taiwan: A Cross-Sectional Survey Study

Journal of Nursing Research, 2014
C. H. Chen, Yu‐Chuan Lin, Li-Ni Liu, S. Tang   +3 more
semanticscholar   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Suicide: The Next Pro-Life Frontier [PDF]

, 1988
Grant, Edward R., Horan, Dennis J.
core   +1 more source

Pulmonologists' experiences with palliative sedation for terminally ill patients [PDF]

Margrethe Aase Schaufel, Rei­dun Før­de, Katrin Ruth Sigurdardottir, Ingrid Miljeteig   +3 more
openalex   +1 more source

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source