Results 41 to 50 of about 80,867 (257)

Survival Prediction of Patients Who Were Terminally Ill Using the EORTC QLQ-C15-PAL Scores and Laboratory Test Values

Palliative Medicine Reports, 2023
Background: Prognostics for patients with cancer is especially important for the supportive care of those who are terminally ill. We previously found that symptom scores as patient-reported outcomes (PROs)?such as dyspnea and fatigue scores?some ...
Chikako Matsumura, Nanako Koyama, Kaho Okuno, Nobuhiko Nakamura, Morito Sako, Hideo Kurosawa, Takehisa Nomura, Yuki Eguchi, Kazuki Ohba, Yoshitaka Yano   +9 more
doaj   +1 more source

Are life-extending treatments for terminal illnesses a special case? Exploring choices and societal viewpoints [PDF]

, 2018
Criteria used by the National Institute for Health and Care Excellence (NICE) to assess life-extending, end-of-life (EoL) treatments imply that health gains from such treatments are valued more than other health gains.
Baker, Rachel, Collins, Marissa, Donaldson, Cam, Godwin, Jon, Mason, Helen, McHugh, Neil, van Exel, Job   +6 more
core   +4 more sources

Nursing and PharmD Undergraduate Students’ Attitude Toward the “Do Not Resuscitate” Order for Children with Terminally Ill Diseases

Journal of Multidisciplinary Healthcare, 2021
Sawsan Abuhammad,1 Suhaib Muflih,2 Karem H Alzoubi,2 Besher Gharaibeh3 1Department of Maternal and Child Health, Jordan University of Science and Technology, Irbid, 22110, Jordan; 2Department of Clinical Pharmacy, Jordan University of Science and ...
Abuhammad S, Muflih S, Alzoubi KH, Gharaibeh B   +3 more
doaj  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Necessary Right of Choice for Physician-Assisted Suicide [PDF]

, 2017
Research-based paper on the importance of the right for terminally ill patients facing a painful death to be able to choose how they end their ...
Ullman, Kerry E.
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Introductory Remarks of Panel II: Legal, Medical, and Ethical Considerations for the Future of Physician-Assisted Suicice Symposium: Physician-Assusted Suicide: Legal Rights in Life and Death: Introductory Remarks of Panel II: Legal, Medicial, and Ethical Considerations for the Future of Physician-Assisted Suicide [PDF]

, 1996
Once the Supreme Court issues it decision in the cases of Quill v. Vacco1 and Compassion in Dying v. Washington2 regarding the constitutionality of outlawing physician-assisted suicide for competent and terminally ill persons, the tension surrounding ...
Hernandez, Tanya K.
core   +1 more source

Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients [PDF]

, 2016
Background and Objective: Morphine dosing can be challenging in terminally ill adult patients due to the heterogeneous nature of the population and the difficulty of accurately assessing pain during sedation. To determine the pharmacokinetics of morphine,
Baar, F.P.M. (Frans), Franken, L.G.W. (Linda), Gelder, T. (Teun) van, Koch, B.C.P. (Birgit), Masman, A.D. (Anniek), Mathot, R.A. (Ron), Tibboel, D. (Dick), Winter, B.C.M. (Brenda) de   +7 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Ultrasound-guided pericapsular nerve group and obturator nerve phenol neurolysis for refractory inpatient hip cancer metastasis pain: a case report

Brazilian Journal of Anesthesiology
Introduction: Bone cancer metastasis may produce severe and refractory pain. It is often difficult to manage with systemic analgesics. Chemical neurolysis may be an effective alternative in terminally ill patients.
Marcio V. Pimenta, Amanda T. Nakamura, Hazem A. Ashmawi, Joaquim E. Vieira, Hermann dos Santos Fernandes   +4 more
doaj   +1 more source