Results 51 to 60 of about 80,867 (257)

The role of end-of-life palliative sedation: medical and ethical aspects - Review [PDF]

Revista Brasileira de Anestesiologia
Background and objective: Palliative sedation is a medical procedure that has been used for more than 25 years to relieve refractory symptoms not responsive to any previous treatment in patients with no possibility of cure and near the end of life.
Miriam S. Menezes, Maria das Graças Mota da Cruz de Assis Figueiredo   +1 more
doaj   +3 more sources

A role for doctors in assisted dying? An analysis of legal regulations and medical professional positions in six European countries [PDF]

, 2008
An extensive debate about assisted suicide and euthanasia has been taking place in westernized countries during the last twenty years. Traditionally, the medical profession has maintained a clear distance from euthanasia and assisted suicide, but this ...
Bosshard, G., Broeckaert, B., Clark, D., Gordijn, B., Materstvedt, L.J., Müller-Busc, C.   +5 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Gap in the Intensity of End-of-Life Care between Younger and Older Taiwanese Adult Cancer Patients may not Reflect Younger Patients’ Preferences

Journal of Cancer Research and Practice, 2015
Background: Studies on age-related differences in preferences for end-of-life (EOL) care have generally concluded that increasing age predisposes patients to prefer less aggressive EOL care. However, these studies seldom are adjusted for healthcare needs,
Siew-Tzuh Tang, Tsang-Wu Liu, Jyh-Ming Chow, Chang-Fang Chiu, Chiun Hsu, Li-Ni Liu, Su-Ching Kuo   +6 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Nurses’ Caring Behavior for Terminally Ill Pediatric Patients.

Journal of Health Science and Medical Research (JHSMR), 2011
Objective: 1) To describe nurses’ caring behavior for terminally ill pediatric patients 2) To identify the relationships between nurses’ caring behavior for terminally ill pediatric patients and personal factors of nurses.
Pranee Rattanaudom, Waraporn Kowthaisong
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Suspending Informed Consent

Voices in Bioethics, 2014
The notion of suspended human animation has long been a topic in science fiction. Whether it is transporting human astronauts to far-off planets or freezing bodily processes for thousands of years, humans have been obsessed.
Dallas M. Ducar
doaj   +1 more source

The assessment of spiritual well-being in cancer patients with advanced disease: which are its meaningful dimensions?

BMC Palliative Care, 2020
Background Spirituality is particularly important for patients suffering from life-threatening illness. Despite research showing the benefits of spiritual assessment and care for terminally ill patients, their spiritual needs are rarely addressed in ...
Elisa Rabitti, Silvio Cavuto, Luca Iani, Simona Ottonelli, Francesco De Vincenzo, Massimo Costantini   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source