Results 61 to 70 of about 80,867 (257)
Facing death in the clinical practice: a view from nurses in Mexico
Salud Pública de México, 2017 Objective. To explore the views of nurses on death in their practice, and their perception about physicians’ actions dealing with terminally ill patients. Materials and methods.
Ma. Luisa Marván +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Консультативная психология и психотерапия, 2015 Metropolitan Anthony was frequently invited to speak by medical institutions, particularly by those caring for terminally ill or dying. In his talk he approaches the notion of the quality of life from an unexpected angle.
Surozhskij A.
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Palliative Care for Terminally Ill Patients Among Nurses and Caregivers in Songklanagarind Hospital
Journal of Health Science and Medical Research (JHSMR), 2013 Objective: 1) to study the level of nurses’ perception about palliative care for terminally ill patients, 2) to study the level of caregivers’ perception about palliative care for terminally ill patients, and 3) to compare perception level among nurses ...
Sirin Sastranuruk +1 more
doaj
Nurses’ Moral Sensitivity Regarding the Terminally Ill
Investigación y Educación en Enfermería, 2019 Objective. The purpose, herein, was to determine the moral sensitivity of nurses when caring for terminally ill patients. Methods. Descriptive study conducted in the city of Cartagena (Colombia) with the participation of 118 nurses with minimum ...
Yolima Carmona González +1 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Parents' Voices Supporting Music Therapy within Pediatric Palliative Care
Voices, 2005 It has been my experience that parents are willing and open to express their voices to promote and advocate for music therapy services for their terminally ill children.
Kathryn Lindenfelser
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source