Results 151 to 160 of about 33,744 (283)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Revisiting Chase Termination for Existential Rules and their Extension to Nonmonotonic Negation

, 2014
International audienceExistential rules have been proposed for representing ontological knowledge, specifically in the context of Ontology-Based Data Access. Entailment with existential rules is undecidable.
Rocher, Swan, Fabien Garreau, Swan Rocher, Baget, Jean-François, Mugnier, Marie-Laure, Jean-Francois Baget, Garreau, Fabien, Marie-laure Mugnier   +7 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Dispatcher-led triage to reduce futile EMS transport for suspected out-of-hospital cardiac arrest in Japan: a narrative review and phased implementation framework. [PDF]

Resusc Plus
Ito Y, Inaba H.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Development of a national consensus guideline for termination of resuscitation in the out-of-hospital environment. [PDF]

Br Paramed J
Smyth MA, Brown TP, Fothergill R, Griffiths F, Lall R, Long J, Petrou S, Siriwardena AN, Slowther AM, Bettely L, Eli K, Gardiner G, Huxley C, Khan K, Michelet F, Perkins GD.   +15 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Empirical Logic for Bio-Inspired Soft Computing: Illustrative Applications in Control Engineering and Cluster Analysis. [PDF]

Biomimetics (Basel)
Grotrian J.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Termination of Rewriting with Right-Flat Rules

, 2008
. Termination and innermost termination are shown to be decidable for rewrite systems whose right-hand side terms are restricted to be shallow (variables occur at depth at most one) and linear.
Ashish Tiwari, Eduard Huntingford, Guillem Godoy   +2 more
core