Results 131 to 140 of about 33,744 (283)

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

A new approach to termination analysis of Constraint Handling Rules

open access: yes, 2007
In this paper, we present a new approach to termination analysis of CHR which is applicable to a much larger class of CHR programs. We propose a new termination condition and show its applicability to CHR programs with rules that are not only of the ...
De Schreye, Danny   +2 more
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Fuzzy sets-based control rules for terminating algorithms

open access: yesComput. Sci. J. Moldova, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Jose L. VERDEGAY, Edmundo VERGARA-MORENO
openaire   +3 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Termination of Croatian citizenship

open access: yes, 2023
Ovaj rad proučava prestanak hrvatskog državljanstva kao temu iz područja upravnog prava. U radu se analiziraju uvjeti i postupak svih triju vrsti prestanka hrvatskog državljanstva za punoljetne i maloljetne osobe te se načini prestanka uspoređuju ...
Žalac, Karolina
core  

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Aplicación de técnicas activas para el control de restricciones en el desarrollo de bases de datos [PDF]

open access: yes, 2006
En las metodologías de desarrollo de BD nos encontramos que los modelos conceptuales que aplicamos son cada vez más ricos y capaces de recoger con mayor precisión las especificaciones del dominio.
Aljumaily, Harith, Al-Jumaily, Harith T.
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

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