Results 111 to 120 of about 33,744 (283)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Rules Termination Analysis investigating the interaction between transactions and triggers
, 2002 We introduce a new method for rule termination analysis within active databases. This method analyzes interaction between transactions and triggers, by means of Evolution Graphs introduced in [16].
Bertino, Elisa +3 more
core
Positive Almost-Sure Termination: Complexity and Proof Rules
Proceedings of the ACM on Programming LanguagesWe study the recursion-theoretic complexity of Positive Almost-Sure Termination (PAST) in an imperative programming language with rational variables, bounded nondeterministic choice, and discrete probabilistic choice. A program terminates positive almost-surely if, for every scheduler, the program terminates almost-surely and the expected ...
Rupak Majumdar, V. R. Sathiyanarayana
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Proving Termination of AC-rewriting without Extended Rules
, 2007 Polynomial interpretations and RPO-like orderings allow one to prove termination of Associative and Commutative (AC-)rewriting by only checking the rules of the given rewrite system without considering the so-called extended rules.
Albert Rubio, Cristina Borralleras
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Termination Analysis of Active Database Rules - Techniques for Increased Precision
, 1998 An active database consists of a traditional database supplemented by a set of Event-Condition-Action (ECA) rules which automatically evaluate conditions and perform actions in response to events.
Alex Poulovassilis, James Bailey
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source