Results 101 to 110 of about 33,744 (283)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A Single Approach to Decide Chase Termination on Linear Existential Rules

, 2018
Existential rules, long known as tuple-generating dependencies in database theory , have been intensively studied in the last decade as a powerful formalism to represent ontological knowledge in the context of ontology-based query answering.
Mugnier, Marie-Laure, Leclère, Michel, Thomazo, Michaël, Ulliana, Federico   +3 more
core   +3 more sources

STATUTORY CANCELLATION OF THE LEASING CONTRACT - CONDITIONS AND EFFECTS [PDF]

Challenges of the Knowledge Society, 2016
The leasing contract termination by cancellation may have both a conventional (commissioria lex) and a legal nature. The legislature has stipulated in the leasing operations governing rules a number of cases in which the parties are entitled to request ...
Raluca Antoanetta TOMESCU
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Modernizing Commercial Agency Regulations in Saudi Arabia: Legal Reforms and Comparative Insights [version 2; peer review: 2 approved, 2 approved with reservations]

F1000Research
Background This study analyzes Saudi Arabia’s 2022–2023 reforms to the Commercial Agency Law through legal, economic, and comparative lenses. The pre-reform regime—marked by rigid nationality limits, procedural burdens, and litigation-prone termination ...
Hajed A. Alotaibi, Abdullah Ali Alasmari
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Modernizing Commercial Agency Regulations in Saudi Arabia: Legal Reforms and Comparative Insights [version 3; peer review: 2 approved, 2 approved with reservations]

F1000Research
Background This study analyzes Saudi Arabia’s 2022–2023 reforms to the Commercial Agency Law through legal, economic, and comparative lenses. The pre-reform regime—marked by rigid nationality limits, procedural burdens, and litigation-prone termination ...
Hajed A. Alotaibi, Abdullah Ali Alasmari
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Modernizing Commercial Agency Regulations in Saudi Arabia: Legal Reforms and Comparative Insights [version 4; peer review: 4 approved]

F1000Research
Background This study analyzes Saudi Arabia’s 2022–2023 reforms to the Commercial Agency Law through legal, economic, and comparative lenses. The pre-reform regime—marked by rigid nationality limits, procedural burdens, and litigation-prone termination ...
Hajed A. Alotaibi, Abdullah Ali Alasmari
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source