Results 71 to 80 of about 33,744 (283)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Growth and size control during development [PDF]
Open Biology, 2017 The size and shape of organs are characteristic for each species. Even when organisms develop to different sizes due to varying environmental conditions, such as nutrition, organ size follows species-specific rules of proportionality to the rest of the ...
Jannik Vollmer +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Stopping rules and memory search termination decisions [PDF]
, 2008 Book synopsis: An important component of many, if not all, real-word retrieval tasks is the decision to terminate memory search. However, despite its importance, no systematic evaluation of the potential rules for terminating search (i.e., potential ...
Davelaar, Eddy J. +4 more
core
Termination analysis of active rules modular sets [PDF]
Proceedings of the tenth international conference on Information and knowledge management, 2001 This paper presents an algorithm for static termination analysis of active rules in a context of modular design. Several recent works have suggested proving termination by using the concept of triggering graph. We propose here an original approach, based on these works, and that allows to guarantee the termination of a set of rules, conceived by ...
openaire +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
A Reduction-Preserving Completion for Proving Confluence of Non-Terminating Term Rewriting Systems [PDF]
Logical Methods in Computer Science, 2012 We give a method to prove confluence of term rewriting systems that contain non-terminating rewrite rules such as commutativity and associativity.
Takahito Aoto, Yoshihito Toyama
doaj +1 more source
A proof rule for fair termination of guarded commands
Information and Control, 1985 Summary: We present a proof rule for fairly terminating guarded commands based on a well-foundedness argument. The rule is applied to several examples, and proved to be sound and (semantically) complete w.r.t. an operational semantics of computation trees. The rule is related to another rule suggested by \textit{D. Lehmann}, \textit{A.
Orna Grumberg +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source