Results 221 to 230 of about 4,238,343 (270)

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Relief of bHD1 autoinhibition and modular coupling support MAT-A pathway activation in Flammulina filiformis. [PDF]

Appl Microbiol Biotechnol
Zhang J, Tian Y, Xiang X, Fan Q, Zhang R.   +4 more
europepmc   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Characterization of Hairpin Loops and Cruciforms Across 118,019 Genomes Spanning the Tree of Life. [PDF]

Genome Biol Evol
Chantzi N, Moeckel C, Chan CSY, Nayak A, Wang G, Mouratidis I, Chartoumpekis D, Vasquez KM, Georgakopoulos-Soares I.   +8 more
europepmc   +1 more source

Multilocus Characterization Reveals Two Geographically Structured <i>Babesia</i> Lineages in Sheep from Southern and Southeastern Kazakhstan. [PDF]

Pathogens
Akhmetova A, Ostrovskii A, Ryskeldina A, Lutsay V, Kadyrova M, Abdigulov B, Karmaliyev R, Shevtsov A.   +7 more
europepmc   +1 more source

Leaky recombinant expression reveals design constraints of bicistronic synthetic operons in Escherichia coli. [PDF]

Sci Rep
Gutmann S, Tauer C, Wagenknecht M, Striedner G, Grabherr R, Cserjan-Puschmann M.   +5 more
europepmc   +1 more source

Identification of proteins exhibiting <i>in vitro</i> RNA chaperone activity through gradient profiling in the Lyme disease spirochete, <i>Borrelia burgdorferi</i>. [PDF]

RNA Biol
Van Gundy T, Schneider C, Ebmeier CC, Chambers GZ, Cramer NA, Chambers KM, Drecktrah D, Hyde JA, Skare JT, Marconi RT, Samuels DS, Lybecker MC.   +11 more
europepmc   +1 more source

PHYCUT: Scalable Multiplex CRISPR/Cas9 Editing for Genome Engineering in the Diatom <i>Phaeodactylum tricornutum</i>. [PDF]

ACS Synth Biol
Stuckless EE, Gai LS, Slattery SS, Dempsey KH, Browne TS, Gloor GB, Edgell DR.   +6 more
europepmc   +1 more source

Genetic and physical mapping in the terminal region of human chromosome 1p

openaire   +1 more source

The White Paper on EU Governance: The Right Tool for the Wrong Means

, 2009
PALERMO, Francesco
core