Results 231 to 240 of about 18,693,829 (332)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Delayed transcriptional response of Daphnia pulex to thermal stress. [PDF]

open access: yesG3 (Bethesda)
Backenstose NJC   +5 more
europepmc   +1 more source

Harmonization of terms used for the morphological description of maize

open access: green, 1986
Philippe Girardin   +3 more
openalex   +1 more source

netwerk-digitaal-erfgoed/network-of-terms: @netwerk-digitaal-erfgoed/network-of-terms-query@6.2.13

open access: green
David de Boer   +9 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

The shifted convolution problem in function fields. [PDF]

open access: yesMath Ann
Florea A, Lalín M, Malik A, Sahay A.
europepmc   +1 more source

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