Results 91 to 100 of about 252,368 (207)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Key theories and technologies and implementation mechanism of parallel computing for ternary optical computer. [PDF]

PLoS One, 2023
Zhang S, Chen J, Liu Z, Wang X, Zhang C, Yang J.   +5 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Performance and energy consumption optimization of ternary optical computers based on the M/G/1 queuing model. [PDF]

Sci Rep
Wenqiang S, Weiwen L, Heqiang Z, Meng L, Sulan Z, Xianchao W.   +5 more
europepmc   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

A 98-qubit trapped-ion quantum computer with all-to-all connectivity. [PDF]

Nature
Ransford A, Allman MS, Arkinstall J, Campora JP, Cooper SF, Delaney RD, Dreiling JM, Estey B, Figgatt C, Hall A, Husain AA, Isanaka A, Kennedy CJ, Kotibhaskar N, Madjarov IS, Mayer K, Milne AR, Park AJ, Reed AP, Ancona R, Andersen MP, Andres-Martinez P, Angenent W, Argueta L, Arkin B, Ascarrunz L, Baker W, Barnes C, Bartolotta J, Berg J, Besand R, Bjork B, Blain M, Blanchard P, Blume-Kohout R, Bohn M, Borgna A, Botamanenko DY, Boutelle R, Brown N, Buckingham GT, Burdick NQ, Burton WC, Carey V, Carron CJ, Chambers J, Chan JW, Children J, Colussi VE, Crepinsek S, Cureton A, Davies J, Davis D, DeCross M, Deen D, Delaney C, DelVento D, DeSalvo BJ, Dominy J, Drotar S, Duncan R, Eccles V, Edgington A, Erickson N, Erickson S, Ertsgaard CT, Esposito J, Evans B, Evans T, Fabrikant MI, Fischer A, Foltz C, Foss-Feig M, Francois D, Freyberg B, Gao C, Garay R, Garvin J, Gaudiosi DM, Gilbreth CN, Giles J, Glynn E, Graves J, Hansen A, Hayes D, Heidemann L, Higashi B, Hilbun T, Hines J, Hlavaty A, Hoffman K, Hoffman IM, Holliman C, Hooper I, Horning B, Hostetter J, Hothem D, Houlton J, Hout J, Hutson R, Jacobs RT, Jacobs T, Johannsen M, Johansen J, Jones L, Julian S, Jung R, Keay A, Klein T, Koch M, Kondo R, Kong C, Kosto A, Lawrence A, Liefer D, Lollie M, Lucchetti D, Lysne NK, Lytle C, MacPherson C, Malm A, Mather S, Mathewson B, Maxwell D, McCaffrey L, McDougall H, Mendoza R, Miller DB, Mills M, Morrison R, Narmour L, Nguyen N, Nugent L, Olson S, Ouellette D, Parks J, Peters Z, Peterson TA, Petricka J, Pino JM, Polito F, Potter AC, Preidl M, Price G, Proctor T, Pugh M, Ratcliff N, Raymondson D, Rhodes P, Roman C, Roy C, Ryan-Anderson C, Sanchez FB, Sangiolo G, Sawadski T, Schaffer A, Schow P, Sedlacek J, Semenenko H, Shevchuk P, Shore S, Siegfried P, Singhal K, Sivarajah S, Skripka T, Sletten L, Spaun B, Sprenkle RT, Stoufer P, Tader M, Taylor SF, Thompson TH, Tobey R, Tran A, Tran T, Vittorini G, Volin C, Walker J, White S, Williams GR, Wilson D, Wolf Q, Wringe C, Young K, Zheng J, Zuraski K, Baldwin CH, Chernoguzov A, Gaebler JP, Sanders SJ, Neyenhuis B, Stutz R, Bohnet JG.   +192 more
europepmc   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source