Results 31 to 40 of about 252,368 (207)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A Connectivity-Aware Via-Programmable DNN Processor Using a Single Photomask

IEEE Open Journal of Circuits and Systems
This paper presents a via-programmable DNN processor architecture, the Via-Programmable Neuron Array (VPNA), designed for low-NRE and low-power AIoT applications.
Jaewon Shin, Mototsugu Hamada, Atsutake Kosuge   +2 more
doaj   +1 more source

Mapping Packet Processing Applications on a Systolic Array Network Processor [PDF]

, 2008
Systolic array network processors represent an effective alternative to ASICs for the design of multi-gigabit packet switching and forwarding devices because of their flexibility, high aggregate throughput and deterministic worst-case performances ...
Rolando, Pierluigi,, HAGSAND O, EKDAHL P., Morandi, Olivier, Olivier Morandi, Risso, Fulvio Giovanni Ottavio, Fulvio Risso, Morandi, Olivier,, Pierluigi Rolando, Ekdahl, P., Rolando, Pierluigi, Olof Hagsand, Hagsand, Olof,, Risso, Fulvio,, Hagsand, O., Peter Ekdahl, Ekdahl, Peter   +16 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Hardware Efficient Speech Enhancement With Noise Aware Multi-Target Deep Learning

IEEE Open Journal of Circuits and Systems
This paper describes a supervised speech enhancement (SE) method utilising a noise-aware four-layer deep neural network and training target switching.
Salinna Abdullah, Majid Zamani, Andreas Demosthenous   +2 more
doaj   +1 more source

Processor-In-Loop hardware setup.

, 2022
Processor-In-Loop hardware setup.
Nik Rumzi Bin Nik Idris (12883823), Muhammad Abbas Abbasi (12883826), Waqas Anjum (8415186), Abdul Rashid Husain (8415189), Hasan Alqaraghuli (8415198)   +4 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source