Results 151 to 160 of about 133,122 (299)

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

High Terpene Production in Myrtaceae: Evolutionary Insights from Terpene Pathway Genes. [PDF]

Plants (Basel)
Chen X, Chen JG, Tuskan GA, Chen F.
europepmc   +1 more source

Mining novel terpene synthases from large-scale repositories

Terpenes and terpenoids represent the largest and most structurally diverse group of natural products, with applications across many fields, including the pharmaceutical industry.
Čalounová, Tereza
core  

Synthesis of -Onoceradiene-like Terpene Dimers by Intermolecular Metathesis Process

, 2006
New a-onoceradiene analogues having a terpene homodimer skeleton are accessible from Weinreb’s amide 2 derived from commercial (R)- (+)-sclareolide using an intermolecular metathesis reaction as the key step to build the linker joining both terpene ...
Pereira, António
core  

Patch Testing in Individuals With Diabetes Using Medical Devices. Part 2—Contact Allergy to Medical Device Allergens and New Patch Test Recommendations

Contact Dermatitis, EarlyView.
This study aimed to describe the prevalence of contact allergy to allergens found in diabetes medical devices (MDs) among diabetes MD users and suggest an updated MD patch test series. Of the 204 diabetes MD users (114 with skin rash to diabetes MDs and 90 without), 16.2% were positive to allergens found in diabetes MDs, which underlines the urgent ...
Josefin Ulriksdotter, Martin Mowitz, Thanisorn Sukakul, Magnus Bruze, Nils Hamnerius, Cecilia Svedman   +5 more
wiley   +1 more source

Resolution of the ABA Biosynthesis Controversy: Discovery of a Dihydroxylating Terpene Synthase and Its Convergent Evolution. [PDF]

ACS Chem Biol
Coca-Ruiz V, Hausmann K, Dräger G, Struwe H, Zahid M, Aleu J, Solle D, Kirschning A, Collado IG, Beutel S.   +9 more
europepmc   +1 more source

Absorption and Effects of Patch Test Preparations of Hydroperoxides of Limonene and Hydroperoxides of Linalool in Human Ex Vivo Skin

Contact Dermatitis, EarlyView.
This study mimics clinical patch testing for the diagnosis of allergic contact dermatitis, by application of patch test preparations of fragrance terpenes to ex vivo human skin samples. The study investigates the penetration of linalool hydroperoxide and limonene hydroperoxide in skin, alongside an analysis of the lipid‐modifying effects of the patch ...
Aoife Clancy, Lina Hagvall, Per Malmberg, Niamh M. O'Boyle   +3 more
wiley   +1 more source

Reinvestigation of the mechanism and selectivity of 1,8-cineole synthase using <i>TerDockin</i>. [PDF]

Chem Sci
Potluri A, Siegel JB, Tantillo DJ.
europepmc   +1 more source

Patch Test Results With Additions to the European Baseline Series, 2021/22—Joint European Results of the ESSCAA and the EBSB Working Groups of the ESCD, and the GEIDACC

Contact Dermatitis, EarlyView.
ABSTRACT Background Allergens are periodically added to the European Baseline Series (EBS) to audit their value in consecutive patch testing. Objectives To present results of audit allergens tested in consecutive patients in 54 departments in 13 European countries during 2021 and 2022.
Wolfgang Uter, Stephen Mark Wilkinson, Andrea Bauer, Leopoldo Borrego, Richard Brans, Timo Buhl, Heinrich Dickel, Rosella Gallo, Ana Giménez Arnau, Margarida Gonçalo, Dimitra Koumaki, Alexander A. Navarini, Cataldo Patruno, Györgyi Pónyai, Thomas Rustemeyer, Radoslaw Spiewak, Luca Stingeni, Skaidra Valiukevičienė, Marie‐L. A. Schuttelaar, Olivier Aerts, the ESSCA, EBS, ESCD working groups, the GEIDAC, Birger Kränke, Ella Dendooven, Dagmar Simon, Philip Spring, Ulrike Beiteke, Cecilia Dietrich, Sibylle Schliemann, Detlef Becker, Swen Malte John, Nicola Wagner, Elke Weisshaar, Stamatis Gregoriou, Maddalena Napolitano, Philippa Cousen, Graham A. Johnston, Juan Francisco Silvestre Salvador, José Manuel Carrascosa Carrillo, Mónica Munera Campos, Esther Serra Baldrich, Gemma Melé‐Ninot, Cristina Barrabés Torrella, David Pesqué, Ana María Giménez Arnau, María Antonia Pastor Nieto, Francisco Navarro Triviño, Leopoldo Borrego, Inmaculada Ruiz Gonzales, Enrique Gómez de la Fuente, Susana Córdoba Guijarro, Francisco Javier Ortiz de Frutos, Fátima Tous Romero, Tatiana Sanz Sánchez, Pablo Chicharro Manso, Marta Andreu Barasoain, Marta Elosua González, Araceli Sánchez Gilo, Paloma Sánchez‐Pedreño Guillén, Pedro Mercader‐García, Carmen Paredes Suárez, María Elena Gatica Ortega, José Juan Pereyra Rodríguez, Javier Miquel Miquel, Mercedes Rodríguez Serna, Violeta Zaragoza Ninet, Ricardo González Pérez   +68 more
wiley   +1 more source

Synthesis of depressin, cryptomeridiol and 4-<i>epi</i>-cryptomeridiol enabled by a terpenoid chiral pool-producing platform. [PDF]

Beilstein J Org Chem
Kong Y, Wang T, Wang C, Zhang P, Liu Y, Wang K, Liu F, Jia H, Xu Z.   +8 more
europepmc   +1 more source