Results 11 to 20 of about 1,155 (183)

An Integrated Nonclinical and Clinical Risk Assessment of the Effects of Investigational ATRi Tuvusertib on QTc Interval in Patients With Solid Tumors. [PDF]

Clin Transl Sci
ABSTRACT Tuvusertib is an investigational, orally administered inhibitor of ATR protein kinase, currently in Phase II clinical development. Here, we present an integrated nonclinical and clinical assessment of the effect of tuvusertib on QTc interval.
Mukker JK, Yap TA, Tolcher AW, de Bono JS, Plummer R, Grosser G, van Amsterdam C, Schieferstein H, Witjes H, Diderichsen PM, Krebs-Brown A, Gao W, Strotmann R, Szucs Z, Gounaris I, Venkatakrishnan K.   +15 more
europepmc   +2 more sources

Pleistocene river diversions caused by large landslides in the western Pyrenees (Oria River drainage basin, N Spain)

Basin Research, Volume 35, Issue 6, Page 2268-2300, December 2023., 2023
Sketches showing the geomorphic features expected after a river is dammed and diverted by a landslide. (a) Pre‐landslide geography. (b) Formation of a lake by landslide damming and eventual overflow. (c) Reconfiguration of the drainage network and catchment boundaries after erosion of the divide.
V. Iribar, B. Ábalos
wiley   +1 more source

Disturbance ecology in human societies

People and Nature, Volume 5, Issue 4, Page 1082-1093, August 2023., 2023
Abstract We define societal disturbances as discrete events that abruptly disrupt the functioning of human societies. There is a variety of such events, including hurricanes, floods, epidemics, nuclear accidents, earthquakes and wars, among others. These disturbances can interact, further increasing their impacts.
Juli G. Pausas, Alexandro B. Leverkus
wiley   +1 more source

Earthquake perception data highlight natural frequency details of Italian buildings

Earthquake Spectra, Volume 39, Issue 2, Page 1240-1254, May 2023., 2023
As the distance from an earthquake increases, the percentage of people who do not feel it also increases. The average transition distance between “felt” and “not felt” reports is mainly determined by the magnitude and depth of the earthquake, but it also depends on the observation floor and building height.
Patrizia Tosi, Valerio De Rubeis, Paola Sbarra   +2 more
wiley   +1 more source

Posttraumatic stress response following the loss of significant close others in the Great East Japan Earthquake: Fukushima Health Management Survey

Journal of Traumatic Stress, Volume 36, Issue 1, Page 129-143, February 2023., 2023
Abstract During the Great East Japan Earthquake, many people experienced the loss of family and friends, among other traumatic events. This study sought to clarify the impact of the loss of significant close others on posttraumatic stress symptoms (PTSS), as well as the factors associated with PTSS, among individuals who experienced the loss of ...
Mayumi Harigane, Satomi Nakajima, Yui Takebayashi, Masaharu Maeda, Hironori Nakano, Seiji Yasumura, Hirooki Yabe, Tetsuya Ohira, Kenji Kamiya, Mental Health Group of the Fukushima Health Management Survey*   +9 more
wiley   +1 more source

The Role of Faults as Barriers in Confined Seismic Sequences: 2021 Seismicity in the Granada Basin (Betic Cordillera)

Tectonics, Volume 41, Issue 9, September 2022., 2022
Abstract Fault barriers are key structures for studying seismic hazard in regions of intense brittle deformation. The interaction between fault sets affects their seismogenic behavior, if some of them act as barriers. The Granada Basin, in the Betic Cordillera, is a region affected by shallow brittle deformation, as it was the scenario for the recent ...
Asier Madarieta‐Txurruka, Lourdes González‐Castillo, José A. Peláez, Manuel Catalán, Jesús Henares, Antonio J. Gil, Francisco Lamas‐Fernández, Jesús Galindo‐Zaldívar   +7 more
wiley   +1 more source

Pre‐ and Co‐Eruptive Analysis of the September 2021 Eruption at Cumbre Vieja Volcano (La Palma, Canary Islands) Through DInSAR Measurements and Analytical Modeling

Geophysical Research Letters, Volume 49, Issue 7, 16 April 2022., 2022
Abstract We investigate the 19 September 2021 eruption of the Cumbre Vieja volcano (La Palma, Canary Islands, Spain). In particular, we analyze the Differential Interferometric Synthetic Aperture Radar (DInSAR) measurements obtained by processing Sentinel‐1 images acquired from both ascending and descending orbits.
C. De Luca, E. Valerio, F. Giudicepietro, G. Macedonio, F. Casu, R. Lanari   +5 more
wiley   +1 more source

Assessing post‐disaster recovery using sentiment analysis: The case of L'Aquila, Italy

Earthquake Spectra, Volume 38, Issue 1, Page 81-108, February 2022., 2022
Memorial days of disasters represent an opportunity to evaluate the progress of recovery. This article uses sentiment analysis (SA) to assess post‐disaster recovery on the 10th anniversary of L'Aquila's earthquake using Twitter data. We have analyzed 4349 tweets from 4 to 10 April 2019 with the hashtag: #L'Aquila that we have obtained from a third ...
Diana Contreras, Sean Wilkinson, Nipun Balan, Philip James   +3 more
wiley   +1 more source

Nuestros terremotos

Salud Pública de México, 2018
El terremoto de septiembre de 2017 sirvió para mostrar el rostro de la sociedad y la cara del Estado. El terremoto dividió en dos a México; uno de ellos, el de la ciudadanía, mostró su solidaridad; el del poder, rezagado e inoperante, quedó relegado ante la fuerza y entrega de la gente. La estructura social permite a las personas crear redes y difundir
Paula Viveros-Wacher, Arnoldo Kraus-Weisman   +1 more
openaire   +1 more source

El Geoportal como vía de acceso a información cartográfica de pronta respuesta. Caso de estudio del sismo de Ecuador en abril del 2016

Revista Cartográfica, 2017
La República de Ecuador es uno de los países donde los desastres naturales constituyen un problema latente debido a factores ligados con la localización de asentamientos humanos en zonas de riesgo.
Martha Villagómez Orozco, Álvaro Dávila Granda, Rosa Cuesta Molestina   +2 more
doaj   +1 more source