Results 121 to 130 of about 153,095 (218)

Ecosystem Resilience and Land-Use Governance: Remote Sensing Insights for Environmental Management in a Tropical Dry Forest. [PDF]

Environ Manage
Nascimento da Silva L, Israel de Souza B.   +1 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Experiences of healthcare access during the COVID-19 pandemic in remote Indigenous communities in Northwest Territories, Canada. [PDF]

Int J Circumpolar Health
Kolahdooz F, Zakkar M, Kolahdooz G, Akbaryan F, Manning C, Wagg A, Rautio A, Pirkola S, Gotay C, DeLancey D, Ferguson G, Conter H, Irlbacher-Fox S, Corriveau A, Sharma S.   +14 more
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Injury Burden in India, 1990 to 2023: National and Subnational Trends From the Global Burden of Disease 2023 Study. [PDF]

Cureus
Kaushik R, Vashistha G.
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Human papillomavirus (HPV) and HPV vaccine awareness in Indigenous communities in Northwest Territories, Canada. [PDF]

PLoS One
Omidimorad A, Kolahdooz F, Kolahdooz G, Wagg A, Veugelers P, Corriveau A, Kandola K, Irlbacher-Fox S, Ogilvie G, Gotay C, Sharma S.   +10 more
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Regional Burden of Spinal Pain in Asia-Pacific Countries and Territories, 1990-2023: A Systematic Analysis for the Global Burden of Disease Study 2023. [PDF]

J Pain Res
Wong TKT, Wong JSH, Wong AYL, Law KKP, Chan DSO, Lau KKL.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source