Results 71 to 80 of about 997,893 (309)

A different appetite for sovereignty? Independence movements in subnational island jurisdictions [PDF]

, 2012
Local autonomy in a subnational jurisdiction is more likely to be gained, secured or enhanced where there are palpable movements or political parties agitating for independence in these smaller territories.
Anckar D., Baldacchino G., Baldacchino G., Baldacchino G., Bartmann B., Bertram G., CIA, Connell J., Elias A., Eve Hepburn, Godfrey Baldacchino, Hepburn E., Hepburn E., Hooghe L., Jeffery C., Keating M., Keating M., Levine S., Loughlin J., McElroy J. L., Miodownik D., Palan R., Palan R., Peckham R. S., Royle S. A., Sidaway J. D., Srebrnik H. F., Türsan H.   +27 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Contribution of organic farming to conserving and improving biodiversity in Germany avi-fauna as an example [PDF]

, 2006
Although it is the aim of organic farming to increase biodiversity, there is little information about the impact of organic farming on birds. From 2001 to 2003, the number of breeding birds was recorded annually on the organic experimental farm of the ...
Haneklaus, S, Hotker, H, Jeromin, K, Paulsen, H, Rahmann, G, Schnug, E, Schrader, S   +6 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Identidades, relaciones internacionales y geopolítica del Caribe: Los actores territoriales de Estados Unidos y la Unión Europea: ¿Un estudio en contrastes?

Études Caribéennes, 2019
The cardinal objective of this paper is to bring to the surface the complex and as yet little explored political and legal relationship between the United States and its overseas territories in the light of a comparative exercise between the American ...
Rafael Cox Alomar
doaj   +1 more source

How good is the European Commission’s Just Transition Fund proposal? Bruegel Policy Contribution Issue n˚4 | February 2020 [PDF]

, 2020
On 14 January 2020, the European Commission published its proposal for a Just Transition Mechanism, intended to provide support to territories facing serious socioeconomic challenges related to the transition towards climate neutrality.
Cameron, Aliénor, Claeys, Grégory, Midoes, Catarina, Tagliapietra, Simone   +3 more
core  

A Whitehall perspective on decentralisation in England’s emerging territories [PDF]

, 2013
Decentralisation is a key thread running through current UK policy making. The Coalition Government has abolished New Labour’s regional legacy in favour of a new set of strategies around growth and development that has tapped into the localist agenda ...
Ayres, Sarah, Pearce, Graham
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source