Results 91 to 100 of about 997,893 (309)

Did Going North Give Us Migraine? An Evolutionary Approach on Understanding Latitudinal Differences in Migraine Epidemiology [PDF]

open access: yes, 2019
This commentary discusses a recent publication by evolutionary biologists with strong implications for migraine experts. The Authors showed that a gene polymorphism associated with migraine gave our ancestors an evolutionary advantage when colonizing ...
Di Piero, V.   +3 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Form and Functions of Intra-Urban Territories in Late Medieval and Early Modern Brussels (15th-16th centuries) [PDF]

open access: yes, 2008
This paper focuses on the spatial analysis of (some specific) intra-urban territories which existed in late medieval and early modern Brussels (Belgium).
Vannieuwenhuyze, Bram
core   +1 more source

The faunistic diversity of cave-dwelling spiders (Arachnida, Araneae) of Greece [PDF]

open access: yes, 2011
Until today, from Greek caves a total of 109 species of spiders belonging to 25 families are known. One species, the linyphiid Porrhomma convexum (Westring, 1861) was recorded here for the first time in Greece. The 109 species are distributed in caves of
Deltshev, Christo
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Identités des Grecs pontiques et caucasiens : le rapport aux lieux et aux territoires

open access: yesCahiers Balkaniques
: the Pontic Greeks and Caucasians came from a very mountainous region on the shores of the Black Sea, characterized by a fragmentation into parallel north-south valleys.
Michel Bruneau
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

De Bahia à Luanda, en passant par Goa : les déclinaisons du gouvernement impérial portugais au XVIIe siècle

open access: yesNuevo mundo - Mundos Nuevos, 2018
This article proposes to explore the government of the Portuguese empire in the seventeenth century, by turning our attention from the metropolitan institutions to the local governmental practices, and to take more into account the territorial dimension ...
Guida Marques
doaj   +1 more source

The Black Frontier [PDF]

open access: yes, 2015
As a nationalistic concept, frontier refers to America\u27s westward expansion, which was propelled in the nineteenth century by Manifest Destiny. Culturally, frontier promises even more: the creation of communities, the development of markets and states,
Nanda, Aparajita
core   +1 more source

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