Results 91 to 100 of about 237,883 (267)

State‐and‐transition simulation models: How can we use them to assess ecosystem condition and support nature markets

Methods in Ecology and Evolution
The world is experiencing a biodiversity crisis. Steep declines in habitat quality and ecosystem services have resulted in interest in markets to help fund ecological restoration.
James M. Furlaud, Katrina Szetey, Kristen J. Williams, Louis Provencher, Suzanne M. Prober, Anna E. Richards   +5 more
doaj   +1 more source

Territories, territorialities and multi-territorialities: The frontier as element of analysis

, 2022
Este artigo tem por objetivo a discussão do conceito de fronteira, dentro de uma perspectiva moderna que inclua as concepções de territórios, territorialidades e multiterritorialidades. Neste contexto, busca-se a compreensão teórica desses conceitos e, na sequência, por meio de três exemplos de fronteiras da atualidade, procura-se estabelecer de que ...
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Feral cats and habitat degradation drive mammal declines in northwestern Australia: An expert elicitation to prioritize management actions

Conservation Science and Practice
As small (
Alyson M. Stobo‐Wilson, Alys Stevens, Sarah M. Legge, Brett P. Murphy, Anna E. Richards, Chris Pavey, Kendrick Bush, Skye F. Cameron, Ben Corey, Teigan Cremona, Jill Curtis, Hugh Davies, Alaric Fisher, Terrah Guymala, Brydie Hill, Alexandra James, Terry Mahney, Norrie Martin, Cecilia Myers, Dominic Nicholls, Cara Penton, Ian J. Radford, Kodjok R. Redford, Alfred Rickson, Angela M. Reid, Berribob‐Dangbungala Watson, Dean Yibarbuk, John C. Z. Woinarski   +27 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

CLOUDY TERRITORIES?

Zygon: Journal of Religion and Science, 2016
The Cloud of Unknowing is a late medieval English mystical text; it has inspired Catherine Keller's title Cloud of the Impossible. A cloud seems fairly diffuse; territory sounds more solid: terra-Earth. However, The Territories of Science and Religion is unsettling for those who assume to be on firm ground when reflecting on religion and on science ...
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source