Results 111 to 120 of about 2,034,257 (312)

Survival of the firm and territory. [PDF]

El objetivo de este trabajo es evaluar el riesgo de mortalidad empresarial. Para ello, en una muestra de más de 11.741 empresas pertenecientes al sector textil-confección se ha estudiado, junto con otros factores, la influencia de la proximidad ...
Belen Garcia-Mora, Cristina Santamaria, Francisco Puig   +2 more
core  

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Feral cats and habitat degradation drive mammal declines in northwestern Australia: An expert elicitation to prioritize management actions

Conservation Science and Practice
As small (
Alyson M. Stobo‐Wilson, Alys Stevens, Sarah M. Legge, Brett P. Murphy, Anna E. Richards, Chris Pavey, Kendrick Bush, Skye F. Cameron, Ben Corey, Teigan Cremona, Jill Curtis, Hugh Davies, Alaric Fisher, Terrah Guymala, Brydie Hill, Alexandra James, Terry Mahney, Norrie Martin, Cecilia Myers, Dominic Nicholls, Cara Penton, Ian J. Radford, Kodjok R. Redford, Alfred Rickson, Angela M. Reid, Berribob‐Dangbungala Watson, Dean Yibarbuk, John C. Z. Woinarski   +27 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

State‐and‐transition simulation models: How can we use them to assess ecosystem condition and support nature markets

Methods in Ecology and Evolution
The world is experiencing a biodiversity crisis. Steep declines in habitat quality and ecosystem services have resulted in interest in markets to help fund ecological restoration.
James M. Furlaud, Katrina Szetey, Kristen J. Williams, Louis Provencher, Suzanne M. Prober, Anna E. Richards   +5 more
doaj   +1 more source

Territory and regional products: an attempt to evaluate the effects of territory information on product price [PDF]

Regions are not mere geographical spaces, being also endowed with specific resources that can be mobilized to increase local producer’s value. Experimental research on Portuguese wine prices contradicted this idea, since region of origin information ...
José Cadima Ribeiro, José de Freitas Santos   +1 more
core  

SHOOTING DOWN THE PRICE: EVIDENCE FROM MAFIA HOMICIDES AND HOUSING MARKET VOLATILITY [PDF]

, 2019
In this work, we assess the role of a specific type of organized crime in influencing choices on where living within the city territory, and consequently, volatility in house prices.
Battisti Michele, Bernardo Giovanni, Lavezzi Andrea Mario, Maggio Giuseppe   +3 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source