Results 121 to 130 of about 1,489,591 (300)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Northern Territory maternal and child health collection 1988

, 1988
This report on Perinatal and Infant Mortality identified by maternal race (Aboriginal or non-Aboriginal) is based on the data prepared for the 18th Northern Territory Maternal and Child Health Committee Meeting held on 18 May 1989 to review data based on
Statistical Services, Durling, Gypsy
core   +1 more source

Corporate Social Responsibility Theories: Mapping the Territory

, 2004
E. Garriga, D. Melé
semanticscholar   +1 more source

Territory Families media release

, 2018
This publication contains may contain links to external sites. These external sites may no longer be active.This publication contains many links to external sites.
Northern Territory. Territory Families
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Northern Territory maternal and child health collection 1986

, 1986
This report on Perinatal and Infant Mortality identified by Maternal race (Aboriginal or non-Aboriginal) is based on the data prepared for the 16th Northern Territory Maternal and Child Health Committee Meeting held on 22 April 1987 to review data based ...
Saint-Yves, Dr. Ian F.M., Epidemiology Branch, Saint-Yves, Dr. Ian F.M   +2 more
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Reimagining artificial intelligence applications for Indigenous‐led community‐based wildlife monitoring: Insights from biodiversity surveys in the Warddeken Indigenous protected area in northern Australia

Conservation Science and Practice
Although conservation science and practice increasingly rely on Artificial Intelligence (AI) wildlife monitoring tools, there is also growing recognition that effective and inclusive conservation depends on collaboration with Indigenous communities. Yet,
Cara E. Penton, Jennifer Mairi Macdonald, Suzanna Nabulwad, Tahnee Nabulwad, Recain Nabarlambarl, Sarah Nabarlambarl‐Billis, Asheena Guymala, Aspelita Guymala, Ashelina Guymala, Alexandria Nabulwad, Maureen Namarnyilk, Erica Smith, Celina Ernst, Ella‐Monique Mason, Alys Stevens, Deborah Nabarlambarl, Catherine J. Robinson   +16 more
doaj   +1 more source

Security, territory, population (Lectures at the College de France)

, 2011
R. Filho, E. Benedito
semanticscholar   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source