Results 91 to 100 of about 4,958,823 (254)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Gender and the tertiary music curriculum in Australia
, 2007 The paper argues that women's music continues to be excluded in tertiary music curricula, translating into the virtual absence of their music on concert platforms.
Macarthur, Sally
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Profile of Dermatophytosis in a Tertiary Care Center in Kerala, India
Indian Journal of Dermatology, 2019 Background: The incidence of dermatophytosis is increasing over the last few years and there are many cases which are recurrent and chronic. Aim: The aim was to study the host and pathogen factors in dermatophytosis, to identify the species responsible, and to study the ...
Mary Vineetha +6 more
openaire +3 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Estimating the Costs of Implementing Comprehensive Primary Care: A Narrative Review
Health Services Research & Managerial Epidemiology, 2019 The performance of the any health-care system relies on a high-functioning primary care system. Increasing primary care practices’ adoption of “comprehensive primary care” capabilities might yield meaningful improvements in the quality and efficiency of ...
Grant R. Martsolf +5 more
doaj +1 more source
Hospital-based surgical case volume and severity of acute appendicitis: 7-year temporal trends (2019–2025) at a Vietnamese tertiary center [PDF]
Journal of Acute Care SurgeryPurpose Acute appendicitis is the most common abdominal surgical emergency worldwide, but hospital-based surgical case volume and disease severity continue to vary over time. Regional differences, the COVID-19 pandemic, and changes in surgical management
Loc Huynh Tran, Hai Van Nguyen
doaj +1 more source
Collaborative national evaluation of Signposts: A professional development resource for new tertiary teachers [PDF]
, 2010 This report describes the context, process and outcomes of a formal evaluation of Signposts, a professional development resource for new tertiary teachers, originally developed in ...
Fraser, Cath +8 more
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
The Health Care Safety Net and Crowd-Out of Private Health Insurance [PDF]
There is an extensive literature on the extent to which public health insurance coverage through Medicaid induces less private health insurance coverage.
Anthony T. Lo Sasso, Bruce D. Meyer
core