Results 101 to 110 of about 5,942 (205)

DeepCARS-Identified High-Risk Patients: Clinical Interventions and Outcomes During the Korean Healthcare Crisis

Medicina
Background and Objectives: Timely recognition of deteriorating ward patients is critical to prevent adverse outcomes. The Deep learning–based Cardiac Arrest Risk Score (DeepCARS), an AI-based early warning system developed in Korea, has demonstrated high
Hyojin Jang, Wanho Yoo, Sora Hwang, Kwangha Lee   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Understanding gaps in guideline-recommended adult congenital heart disease care: Data from 12 US health care centers

•Adults with CHD at tertiary centers have significant gaps in recommended ACHD care.•Nonsevere CHD, nonphysiologic class conditions, and age 40+ have higher care gaps.•Patients with gaps in specialist visits have higher gaps in recommended testing.•COVID-
Roeder, Mark, Sandhu, Satinder, Jacobsen, Roni, Agarwal, Anushree, Congenital Heart Initiative-Redefining Outcomes and Navigation to an Adult-centered Care (CHI-RON) Investigators, Leezer, Scott, Lubert, Adam, Singh, Harsimran, Lewis, Matthew, Zaidi, Ali, Halpern, Dan G., Rudov, Lindsey, John, Anitha S., Mehta, Rittal, Jackson, Jamie L., Bayne, Joseph, Duan, Rong, Kanter, Ronald, Ruckdeschel, Emily, Carton, Thomas, Saidi, Arwa, Phillippi, Ruth, Young, Thomas, Saraf, Sneha   +23 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Patient self-referral patterns in a developing country: characteristics, prevalence, and predictors

BMC Health Services Research
Background Efficient healthcare delivery and access to specialized care rely heavily on a well-established healthcare sector referral system. However, the referral system faces significant challenges in developing nations like Bangladesh.
Mohammad Jahid Hasan, Md. Abdur Rafi, Nahida Hannan Nishat, Ima Islam, Nusrat Afrin, Bikona Ghosh, Etminan Kabir, Samiha Zaman Akhter, Maisha Zaman Poushi, Saadi Abdullah Bin Shahnoor, Jannatul Fardous, Tamanna Tabassum, Sadia Islam, Sumiya Bent Kalam, Mehjabeen Tasnuva Aslam, Taufique Joarder   +15 more
doaj   +1 more source

Ocular morbidity, visual impairment and its association with social factors in children attending primary healthcare services for any health-related problem in Pavagada, India – A health facility-based cross-sectional study

Indian Journal of Ophthalmology
Background: Primary eye healthcare in India has potential for improvement; enhancing it can play a role in universal health coverage, integrated people-centered eye care, and reducing the burden on overloaded secondary/tertiary facilities.
Vasudha Kemmanu, Piyush V Naresh, Catey Bunce, Keerthi P Hudedagaddi, D Abhishek, G R Chandrakala, Richard Bowman, Aeesha N J Malik   +7 more
doaj   +1 more source

Intravenous Artesunate for Imported Severe Malaria in Children Treated in Four Tertiary Care Centers in Germany: A Retrospective Study

, 2019
BACKGROUND: Intravenous artesunate (ivA) is the standard treatment for severe malaria. Data systematically evaluating the use of ivA in pediatric patients outside malaria-endemic regions are limited.
Janda, Ales, Gratopp, Alexander, Brand, Judith, Suttorp, Norbert, Schulze-Sturm, Ulf, Hufnagel, Markus, Blohm, Martin, Zoller, Thomas, Hübner, Johannes, Stegemann, Miriam S., Reiter, Karl, Bélard, Sabine, Kempf, Caroline, Kobbe, Robin, Kurth, Florian, von Both, Ulrich, Mall, Marcus, Varnholt, Verena, Krüger, Renate, Tacoli, Costanza, Bernuth, Horst von, Both, Ulrich von, von Bernuth, Horst, Alberer, Martin   +23 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Survival, virological and immunological outcomes of HIV-infected children accessing ART at South African primary health care clinics

, 2013
Includes bibliographical references.South Africa faces the world’s largest pediatric HIV epidemic. Combination antiretroviral therapy (ART) is the only effective treatment for HIV virus suppression.
Morsheimer, Megan
core  

The use of complementary medicine in palliative care in France: an observational cross-sectional study.

, 2020
PURPOSE:Palliative care for cancer deals with physical, psychosocial, and spiritual issues faced by cancer patients, their families, communities, and healthcare providers.
Maret, J-B, Palmgren, PJ, Filbet, M, Steel, A, Diezel, H, Schloss, J   +5 more
core   +1 more source