The Prescription Pattern, Care-Seeking Behavior and Glycemic Status Among the Diabetic Patients in a Tertiary-Level Hospital of Bangladesh: A Cross-Sectional Observational Study. [PDF]
Health Sci RepSweet MSR +4 more
europepmc +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Implementation uptake and healthcare worker adherence following a World Health Organization-aligned multi-modal infection prevention and control intervention in Bangladeshi tertiary hospitals: a multi-centre comparative study. [PDF]
Infect Prev PractSumon SA +12 more
europepmc +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Does Hospital Accreditation Increase Inpatient Expenditure and Improve Quality of Care? Evidence from Heart Failure Admissions in County-Level Public Hospitals in China. [PDF]
Risk Manag Healthc PolicyTan H, Fang H.
europepmc +1 more source
Tertiary activities and informality: quantitative importance and interconnections within the economy in Brazil [PDF]
This paper studies the importance of the Tertiary sector and the informal sector for the Brazilian economy, making an interconnection between them and with them and the rest of the economy and the formal sector.
Guilhoto, Joaquim José Martins +1 more
core
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Recent advances in synthesis of nitrogen-centered chiral compounds. [PDF]
RSC AdvWang ZH, Ji W, Lin TY.
europepmc +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Female sexual dysfunction in premenopausal women with diabetes mellitus in northern Nigeria: A cross-sectional study from two tertiary hospitals examining associations with glycaemic control and reproductive hormones. [PDF]
PLoS OneDamagum FM +14 more
europepmc +1 more source