Results 111 to 120 of about 432,156 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The evaluation of a tertiary-level distance-mode aural training programme

, 2008
The purpose of the study was to determine whether a prototype aural training programme could successfully develop tertiary level aural training skills if face-to-face teaching components were replaced entirely by interactive CD-ROM delivery.
Gearing, Phillip John
core  

Indicators of hot fluid migration in sedimentary basins: evidence from the UK Atlantic Margin [PDF]

, 2003
Microthermometric, petrographic and isotopic methods have been used to detect evidence for hot fluid flow in Mesozoic and Tertiary sediments from the NW UK continental margin, West of Shetland. New data presented here show that temperatures are hotter by
H. L. Wycherley, J. Parnell, Wycherley, H.L., Boyce, A.J., Watt, G.R., Chen, H., H. Chen, G. R. Watt, Parnell, J., A. J. Boyce   +9 more
core  

Exploring the spectrum: A comprehensive review of control methods in microgrid systems

Results in Engineering
Recent developments in renewable energy technologies have motivated the researchers to focus their studies on control systems. The increasing adoption of renewable energy sources has alsoincreased the interest in control systems for microgrids and ...
Sujit Kumar, M Premkumar, Jayant Giri, Sasanka Sekhor Sharma, S M Mozammil Hasnain, T Sathish, Rustem Zairov   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

BUSINESS RISK CONTROL PRACTICES AND ENTREPRENEURIAL EDUCATION AMONG SELECTED STUDENTS IN LAGOS STATE OWNED TERTIARY INSTITUTIONS

Malete Journal of Accounting and Finance
Entrepreneurial education is core strategic development of any emerging nation whose aim is creating value addition environs for her people. Therefore, this study examines the relationship between business risk control practices and entrepreneurial ...
Oluwatoyin Frederick IDOWU, Sunday Stephen AJEMUNIGBOHUN   +1 more
doaj  

Evaluation of a Three-Level Cascade Soilless System Under Saline Greenhouse Conditions

Horticulturae
A three-level cascade hydroponic system was designed to enhance resource efficiency by reusing drainage solutions across sequential crops: tomato (primary-donor crop), herbs (mint, peppermint; secondary receivers from primary), and halophytes (lemon balm,
Eleni Karatsivou, Angeliki Elvanidi, Nikolaos Katsoulas   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source