Results 81 to 90 of about 407,199 (267)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Impact of coronavirus disease 2019 on the utilization of hospital services and development of optimal pandemic control strategy in Chinese tertiary hospitals during the Omicron wave

BMC Health Services Research
Background This study aimed to assess the impact of coronavirus disease 2019 (COVID-19) on hospital service utilization and revenue in Chinese tertiary hospitals and develop an optimal pandemic control strategy (OPCS) for the peak period of the Omicron ...
Dan Yu, Dong Wang, Yi Chen, Ting Dong, Yinchu Zhang, Mengjun Huang, Anhua Wu, Yi Ouyang, Wendong Chen, Zhaoxin Qian   +9 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Diabetes Mellitus and Oral Health Status: A Case-Control Study in a Tertiary Care Hospital in Bangladesh

Update Dental College Journal
Introduction: Diabetes is a long-lasting, inflammation-related metabolic disorder which is diagnosed by hyperglycemia. Increased blood glucose level adversely impacts the inflammatory response to periodontium leading to more severe gingivitis and ...
Jesmin Sultana Lucky, Mohammad Anayet Hossain, Dilruba Binte Mostafa, Mohammad Mobashir, Tahnia Binta Nasir, Asadur Rahman, Sadia Parvin   +6 more
doaj   +1 more source

INTERNAL AUDIT QUALITY AND PERFORMANCE OF PUBLIC TERTIARY INSTITUTIONS IN OSUN STATE, NIGERIA

Malete Journal of Accounting and Finance, 2023
Despite the presence of internal audit mechanism in most public tertiary institutions, evidence has shown that most of them have experienced audit failure in recent years with consequential effect on the effectiveness and efficiency in quality of ...
Khadijah Adeola IDOWU, IBRAHIM Jimoh
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Tertiary Education and Economic Growth in Tanzania [PDF]

International Journal of Management, Accounting and Economics
The study examines how tertiary education impact economic growth in Tanzania, time series secondary data spanning from the year 1999 to 2023 were extracted from World Bank database.
Kembo Bwana, Jeremiah Tumaini, Galan Mashenene   +2 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Aseptic technique training and infection-risk reduction practices among healthcare workers

Diversity
Healthcare-associated infections (HAIs) remain a persistent burden in resource-limited health systems, yet evidence on structured, sustained aseptic technique education for healthcare workers (HCWs) in Nigerian tertiary hospitals is still limited.
Abdulmuhit Temitope Isiaq, Seun Nurudeen Akorede, Adamu Abdulkareem Biu, Muhammad Sanusi   +3 more
doaj   +1 more source

Land And Water Management Option of Tidal Lowland Reclamation Area to Support Rice Production (A Case Study in Delta Sugihan Kanan of South Sumatra Indonesia)

Journal of Wetlands Environmental Management, 2018
The main problem for agriculture at tidal lowland swamp is low soil quality and high acidity of soil and high water. The research objective was to investigate how far the effort in increasing tertiary canal network to improve water quality (increasing pH
Momon Sodik Imanudin, Bakri Bakri, Muhammad Edi Armanto, Budi Indra Setiawan, Ratmini S NP   +4 more
doaj   +1 more source