Results 101 to 110 of about 519,687 (316)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Prevalence and causes of blindness at a tertiary hospital in Douala, Cameroon

, 2011
André Omgbwa Eballé1,4, Côme Ebana Mvogo1,3, Godefroy Koki2, Nyouma Mounè3, Cyrille Teutu5, Augustin Ellong2,3, Assumpta Lucienne Bella2,41Faculty of Medicine and Pharmaceutical Sciences, University of Douala ...
Koki G, Nyouma Moune E, Bella AL, Teutu C, Ellong A, Eballé AO, Mvogo CM, Andre Eballe   +7 more
core   +1 more source

The experiences of rural and remote families involved in an inter-hospital transfer to a tertiary ICU: A hermeneutic study [PDF]

, 2014
Background: Inter-hospital transfers are necessary for critically ill patients to improve their chance of survival. Rural and remote families experience significant disruption to family life when critically ill patients are required to undergo a transfer
Kellett, U, Angela Tonge, Mackie, Benjamin R, Ursula Kellett, Mitchell, Marion, Mitchell, M, Kellett, Ursula Marie, Mitchell, Marion Lucy, Mackie, Benjamin, Benjamin Mackie, Tonge, A, Kellett, Ursula, Marion Mitchell, tonge, Angela   +13 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Prevalence of Rotavirus and Adenovirus in the Childhood Gastroenteritis in a Tertiary Care Teaching Hospital

, 2019
Gastroenteritis in the childhood is one of the most common cause of morbidity and mortality throughout the world. Acute gastroenteritis is caused by bacteria, viruses, parasites, and rarely fungi.
Krishnappa J., Arvind N., Sushma M.
core   +1 more source

Maternal mortality from eclampsia at tertiary referral hospital, Surabaya, Indonesia [PDF]

, 2020
Globally, ten million women experience preeclampsia every year. This study aimed to analyze maternal death caused by eclampsia at Dr. Soetomo General Hospital, Surabaya, Indonesia from January 2015 to December 2016.
Agus Sulistyono, Yustinasari, Hermanto Tri Joewono, Aditiawarman   +3 more
core  

Refractory cardiogenic shock due to atomoxetine overdose rescued by venoarterial extracorporeal membrane oxygenation: A case report

Acute Medicine & Surgery
Background Atomoxetine, a selective norepinephrine reuptake inhibitor for attention‐deficit hyperactivity disorder, may lead to severe complications, notably cardiac issues, upon overdose.
Kenta Komoriya, Kanta Kitagawa, Yutaka Mihara, Kei Hagiwara, Yasuhito Hatanaka, Mayu Hikone, Kazuhiro Sugiyama   +6 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Imported infectious diseases in tertiary hospitals

Anales de Pediatría (English Edition), 2014
An Imported Diseases Clinic was created in the hospital in 2009. The aim of this study was to asses its contribution in terms of capacity, quality of care and teaching offered.A retrospective study was conducted from 2009 to 2011, analyzing: A) development of knowledge by means of protocols and publications created, and subject taught; B) capacity and ...
N, Rius Gordillo, A, Martín Nalda, S, Otero Romero, P, Soler-Palacín, E, Sulleiro Igual, M, Espiau Guarner, A, Fernández-Polo, C, Figueras Nadal   +7 more
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source