Results 51 to 60 of about 12,337 (202)

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Thrombosis in myeloproliferative neoplasms: Treatment outcomes of direct oral anticoagulants and vitamin K antagonists

Research and Practice in Thrombosis and Haemostasis, 2021
Background Patients with myeloproliferative neoplasms (MPNs), such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are at an increased risk of recurrent thromboembolic events (TEs) and hemorrhagic complications.
Kateryna Fedorov, Swati Goel, Margarita Kushnir, Henny H. Billett   +3 more
doaj   +1 more source

Influence of TES-therapy on the character of stress-induced expression of C-FOS in the paraventricular nucleus of the hypothalamus [PDF]

, 2017
In this study, the ability of transcranial electrostimulation (TES-therapy) to inhibit the hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis (reflected in the change in the character of c-fcs expression by neurons in the paraventricular ...
Gasparyan, K. K., Gubareva, E. A., Kade, A. H., Kuevda, E. V., Lipatova, A. S., Polyakov, P. P., Sotnichenko, A. S., Гаспарян, К. К., Губарева, Е. А., Каде, А. Х., Куевда, Е. В., Липатова, А. С., Поляков, П. П., Сотниченко, А. С.   +13 more
core  

Cognitive neural prosthetics – the way from experiment to clinical application [PDF]

, 2021
Accepted: September 3, 2021. Objective of this review is to highlight some aspects of the development and use of cognitive neuroprostheses, such as the technological background for their developing and key modern projects in this field.
A. I. Trofimenko, A. Kh. Kade, S. P. Vcherashnyuk, S. V. Kravchenko, V. V. Malyshko   +4 more
core   +2 more sources

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Nonmedical methods of psychosomatic pathology correction in teenagers [PDF]

, 2012
According to the method of treatment of chronical gastropathology teenagers were divided into mail groups and a control group (414 people). In main groups basic therapy of gastropathology was combined with transcranial electrostimulation on the apparatus
Nechaeva, I. A., Vavilov, A. M., Vavilova, V. P., Vavilova, Т. А., Вавилов, А. М., Вавилова, В. П., Вавилова, Т. А., Нечаева, И. А.   +7 more
core  

Intra-cluster correlation coefficients in adults with diabetes in primary care practices: the Vermont Diabetes Information System field survey [PDF]

, 2006
BACKGROUND: Proper estimation of sample size requirements for cluster-based studies requires estimates of the intra-cluster correlation coefficient (ICC) for the variables of interest.
A Donner, Benjamin Littenberg, C Bradley, C Bradley, CD MacLean, Charles D MacLean, CR Elley, DJ Toobert, DR Parker, DW Baker, G Adams, J Cohen, JA Ewing, JE Ware, JN Katz, JR Gleason, K Kroenke, K Strauss, L Smeeth, MC Gulliford, MK Campbell, O Sangha, RM Parker, SA Knox, SM Kerry, SM Kerry, Stata Corporation, Vermont Program for Quality in Health Care, WT Friedwald   +28 more
core   +3 more sources

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

DYNAMICS OF LEVEL B-ENDORPHINS AT MODELLING OF THE ISCHEMIC STROKE AT RATS

Кубанский научный медицинский вестник, 2014
The problem of treatment of the ischemic stroke (IS) is actual in modern medicine. In work an attempt of creation of model of cerebral ischemia at rats with possibility of application of TES-therapy is made.
A. I. Trofimenko, A. Kh. Kade, F. A. Nehaj, V. P. Lebedev, V. D. Levichkin, S. A. Zanin   +5 more
doaj  

PTSD, dysregulation profile and substance use: exploring differences in a sample of adolescents in an outpatient clinic

Frontiers in Child and Adolescent Psychiatry
IntroductionExperiencing traumatic events (TEs), especially interpersonal TEs, is related to an increased risk of developing post-traumatic stress disorder (PTSD).
Emely Reyentanz, Emely Reyentanz, Lukas A. Basedow, Veit Roessner, Yulia Golub, Yulia Golub   +5 more
doaj   +1 more source