Results 51 to 60 of about 12,489 (231)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

An exploratory cohort study of serum estradiol, testosterone, osteoprotegerin, interleukin-6, calcium, and magnesium as potential biomarkers of cervical spondylosis

Bulletin of Faculty of Physical Therapy, 2023
Background Exploration of biomarkers for debilitating diseases such as cervical spondylosis is important to revolutionize clinical diagnosis and management of such conditions.
Augustine Asiduba Igwe, Ogochukwu Kelechi Onyeso, Israel Adandom, Kelechi Mirabel Onyeso, Canice Chukwudi Anyachukwu, Oluwagbohunmi A. Awosoga, Charles Ikechukwu Ezema, Goddy Chuba Okoye   +7 more
doaj   +1 more source

Thrombosis and Major Bleeding Risk After Primary PCI Among Patients With Multivessel Coronary Artery Disease

Frontiers in Cardiovascular Medicine, 2022
Background and AimThis study aimed to develop and validate separate risk prediction models for thrombosis events (TEs) and major bleeding (MB) in patients with multivessel coronary artery lesions who had undergone primary percutaneous coronary ...
Xiaoxiao Zhao, Chen Liu, Peng Zhou, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Runzhen Chen, Ying Wang, Yi Chen, Li Song, Hanjun Zhao, Hongbing Yan   +11 more
doaj   +1 more source

Результати дослідження стресових реакцій у хворих із поєднаною травмою середньої зони обличчя після застосування комплексної післяопераційної реабілітації [PDF]

, 2020
Summary. The frequency of the midface bone demages area occupy the second place among the all maxillo-facial fractures. In all cases, these injuries are accompanied by multiple, often multi-fragmented fractures of zygomatic-orbital complex.
Ilnytskyi, Ya. M., Melnychuk, Yu. M., Nazarevych, M. R., Ohonovskyi, R. Z., Pohranychna, Kh. R.   +4 more
core   +2 more sources

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Influence of TES-therapy on the character of stress-induced expression of C-FOS in the paraventricular nucleus of the hypothalamus [PDF]

, 2017
In this study, the ability of transcranial electrostimulation (TES-therapy) to inhibit the hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis (reflected in the change in the character of c-fcs expression by neurons in the paraventricular ...
Gasparyan, K. K., Gubareva, E. A., Kade, A. H., Kuevda, E. V., Lipatova, A. S., Polyakov, P. P., Sotnichenko, A. S., Гаспарян, К. К., Губарева, Е. А., Каде, А. Х., Куевда, Е. В., Липатова, А. С., Поляков, П. П., Сотниченко, А. С.   +13 more
core  

Testosterone May Hold Therapeutic Promise for the Treatment ofIschemic Stroke in Aging: A Closer Look at Laboratory Findings [PDF]

, 2019
Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebralischemia remains unclear. Here we reviewed current understanding of testosterone (TES)neuroprotective activity against ischemic stroke and mechanisms ...
Alireza Majdi, Fereshteh Farajdokht, Javad Mahmoudi, Masumeh Zamanlu, Mehdi Farhoudi, Saeed Sadigh-Eteghad, Shabnam Vahedi   +6 more
core   +1 more source

Surface‐Capped Protein Nanoparticles for Nonviral Gene Delivery

Advanced Materials, EarlyView.
ABSTRACT Developing simple, safe, and efficient nonviral delivery systems remains a significant challenge in bioengineering. Nanoparticles offer promising gene delivery capabilities with reduced toxicity; however, long‐standing challenges related to effective plasmid encapsulation and delivery exist.
Fjorela Xhyliu, Yao Yao, Yeongun Ko, Grant Grasman, Jeffery E. Raymond, Albert Chang, Yuxuan Deng, Grant Dominic, Michael Triebwasser, Joerg Lahann   +9 more
wiley   +1 more source

PTSD, dysregulation profile and substance use: exploring differences in a sample of adolescents in an outpatient clinic

Frontiers in Child and Adolescent Psychiatry
IntroductionExperiencing traumatic events (TEs), especially interpersonal TEs, is related to an increased risk of developing post-traumatic stress disorder (PTSD).
Emely Reyentanz, Emely Reyentanz, Lukas A. Basedow, Veit Roessner, Yulia Golub, Yulia Golub   +5 more
doaj   +1 more source

Thrombosis in myeloproliferative neoplasms: Treatment outcomes of direct oral anticoagulants and vitamin K antagonists

Research and Practice in Thrombosis and Haemostasis, 2021
Background Patients with myeloproliferative neoplasms (MPNs), such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are at an increased risk of recurrent thromboembolic events (TEs) and hemorrhagic complications.
Kateryna Fedorov, Swati Goel, Margarita Kushnir, Henny H. Billett   +3 more
doaj   +1 more source