Results 61 to 70 of about 12,337 (202)

Factors determining the prognosis after elective myocardial revascularization in patients with coronary artery disease with multifocal atherosclerosis

open access: yesКардиоваскулярная терапия и профилактика, 2023
Aim. To identify factors determining the prognosis after elective myocardial revascularization in patients with coronary artery disease (CAD) with multifocal atherosclerosis (MFA).Material and methods.
M. B. Khakimova   +7 more
doaj   +1 more source

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

open access: yesAdvanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta   +7 more
wiley   +1 more source

THE ALGORITHMS OF EXAMINATION OF PATIENTS WITH THYROID NODULES FORMATIONS: MODERN STATE OF THE QUESTION AND OUR OWN EXPERIENCE

open access: yesКубанский научный медицинский вестник, 2016
We conducted a research of the following ways of the post-operative hypothyroidism treatment: CES-therapy, hormone replacement therapy with L-thyroxine and combination therapy including two previously suggested approaches.
A. KH. Kade   +5 more
doaj  

Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens

open access: yesBiology of Sex Differences, 2020
Background Acutely, testosterone (TES) and other androgens are efficacious vasodilators, both in vitro and in vivo; however, their long-term effects on arterial blood pressure (BP) remain unclear.
Andrea E. Hanson   +2 more
doaj   +1 more source

Expressive Writting Therapy Dalam Menurunkan Kecemasan Pada Korban Bullying

open access: yesJurnal Diversita, 2023
Bullying adalah bentuk kekerasan pada anak yang menimbulkan kesengsaraan dan penderitaan baik secara fisik maupun psikologis. Kejadian bullying pada remaja yang cukup tinggi menyebabkan gangguan kecemasan yang berdampak buruk bagi kehidupan individu ...
Nursan Junita   +5 more
doaj   +1 more source

Patient-reported outcomes in a trial of exenatide and insulin glargine for the treatment of type 2 diabetes [PDF]

open access: yes, 2006
BACKGROUND: Patient-reported measures can be used to examine whether drug differences other than clinical efficacy have an impact on outcomes that may be important to patients.
A Richter   +75 more
core   +3 more sources

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

open access: yesAdvanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu   +14 more
wiley   +1 more source

Dynamics of proinflammatory cytokines level in stable angina (II–III functional class)

open access: yesСеченовский вестник, 2016
The article discusses the evaluation of cytokine level (IL-1β, IL-6) in patients with II–III functional class stable angina. In the group of patients with II–III class stable angina, the standard therapy failed to normalize the level of proinflammatory ...
E. K. Gordeeva, A. H. Kade, S. A. Zanin
doaj  

Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

open access: yesAdvanced Science, EarlyView.
Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go   +12 more
wiley   +1 more source

Dynamic Decoration of DNA Scaffolds for High‐Resolution Cancer Cell Subtyping

open access: yesAdvanced Science, EarlyView.
This study presents a dual‐mode imaging platform that utilizes self‐assembly and disassembly of DNA scaffolds for high‐resolution cancer cell detection. The structural rigidity of DNA scaffolds effectively prevents cellular internalization for over 300 min.
Xiaolin Hu   +15 more
wiley   +1 more source

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