Results 81 to 90 of about 12,337 (202)

Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
Schematic illustration of mTEM8‐loaded cationic liposome (cLipo‐Man/mTEM8) therapeutics for improved triple‐negative breast cancer immunotherapy. Despite triple‐negative breast cancer (TNBC) is the most heterogeneous and aggressive subtype of breast cancer, immunotherapy is emerging as a promising therapy.
Kexin Deng, Juping Sun, Junyu Liu, Yuqi Zhang, Wanwan Liu, Xiaobin Li, Han Wu, Juan Li, Jisong Zhang, Chanyuan Jin, Can Yang Zhang   +10 more
wiley   +1 more source

Testosterone May Hold Therapeutic Promise for the Treatment ofIschemic Stroke in Aging: A Closer Look at Laboratory Findings [PDF]

, 2019
Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebralischemia remains unclear. Here we reviewed current understanding of testosterone (TES)neuroprotective activity against ischemic stroke and mechanisms ...
Alireza Majdi, Fereshteh Farajdokht, Javad Mahmoudi, Masumeh Zamanlu, Mehdi Farhoudi, Saeed Sadigh-Eteghad, Shabnam Vahedi   +6 more
core   +1 more source

Improved Messenger RNA Stability and Biocompatibility Through Self‐Gelatinizable Nucleic Acids

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Recent advances in the chemical synthesis and modification of messenger RNA (mRNA) have generated growing interest in mRNA‐based therapeutics. However, the inherent instability of mRNA in vivo and during storage remains a major challenge, requiring the development of safe and effective delivery systems.
Takumi Tanifuji, Kosuke Kusamori, Chihiro Tanaka, Hideki Sakai, Shoko Itakura, Makiya Nishikawa   +5 more
wiley   +1 more source

Transcranial electrostimulation in patients with alcoholic encephalopathy [PDF]

Саратовский научно-медицинский журнал, 2010
The method of transcranial electrostimulation (TES) was used for treating patients with alcoholic encephalopathy against the background of the basic treatment, which includes nootropics, normotimics, soporifics, over-all strengthening therapy and other ...
Barylnik Yu.B., Lim V.G., Shchetinin S.G.   +2 more
doaj  

Supervised and Unsupervised Approaches for the Real-Time Detection of Undesired Insulin Suspension Caused by Malfunctions [PDF]

Background: Automated insulin delivery (AID) systems, permit improved treatment of type 1 diabetes (T1D). Unfortunately, malfunctioning in the insulin pump or in the infusion set can prevent insulin from being administered, reducing the AID efficacy and
Del Favero, Simone, Facchinetti, Andrea, Idi, Elena, Sparacino, Giovanni   +3 more
core   +1 more source

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

BMEMat, EarlyView.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang, Zehao Shen, Guangming Xiang, Zhe Liu, Huaxin Liu, Jiabei Li, Ao Wang, Yelin Wu, Peiran Zhao, Xingwu Jiang, Jinghan Wang, Xiaoqing Jiang, Wenbo Bu   +12 more
wiley   +1 more source

Nervous system behavior simulation under electrostimulation [PDF]

, 2021
Обсяг роботи становить 63 сторінки, міститься 28 ілюстрацій, 22 формули, 16 таблиць. Загалом опрацьовано 43 джерела. Актуальність: відсутність вітчизняної обґрунтованої теоретичної бази впливу tDCS на мозок людини. та відповідних приладів.
Пінеда Чамба, Стефані Патрісіа
core  

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

GERD and Upper Aerodigestive Tract Cancer Risk: A Systematic Review and Meta‐Analysis

The Laryngoscope, EarlyView.
ABSTRACT Objective Gastroesophageal reflux disease (GERD) is highly prevalent, yet its association with upper aerodigestive tract (UADT) cancers beyond esophageal adenocarcinoma remains incompletely defined. This systematic review and meta‐analysis aimed to quantify the risk of specific UADT cancers in individuals with GERD.
Janice Huang, Nicolas Jo, Garret Forman, Tonya Aaron, Sophia Peifer, Soumil Prasad, Luke van Leeuwen, Laura Wild, Nicholas DiStefano, Zhibin Chen, Elizabeth Franzmann   +10 more
wiley   +1 more source

Evaluating the impact of transcranial electrical stimulation on post-stroke dysphagia: a systematic review and meta-analysis

Journal of International Medical Research
Objective To conduct a systematic review and meta-analysis to assess the impact of transcranial electrical stimulation (TES), proposed as a potential therapy for post-stroke dysphagia, on swallowing function in stroke survivors.
Yanan Zhao, Zhicheng Zhang, Cuicui Wang, Hui Zhang, Ying Wang, Jing Bian   +5 more
doaj   +1 more source