Results 261 to 270 of about 15,644,828 (310)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Changes in the life history traits in Aedes aegypti selected for resistance to permethrin and thymol, a spatial repellent. [PDF]

PLoS One
Smartt CT, Farless S, Kendziorski NL, Chen TY, Tian Y, Alto BW, Allan SA, Lord CC.   +7 more
europepmc   +1 more source

Effects of hexavalent chromium on the biology of Steinernema feltiae: evaluating sublethal endpoints for ecotoxicity testing

Anique Godjo, D. G.M. Donald, Lucile Ansaldi, I. H. Darwish, John Byrne, Thomais Kakouli‐Duarte   +5 more
openalex   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Thrombocytopenia in patients with Plasmodium vivax in Colombia is associated with anti-phosphatidylserine autoantibodies and IL-6, IFNγ, IL-10 and TGF-β. [PDF]

PLoS Negl Trop Dis
Velasco-Pareja MC, Tovar-Acero C, Cantero Guevara ME, Rodriguez A, Rivera-Correa J, Yasnot-Acosta MF.   +5 more
europepmc   +1 more source

Teaching Reform of General Biology Based on Vocational Competency Development in Food Inspection and Testing Programs

openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Harnessing the highly adaptable barnase-barstar system for genetic biocontrol of Aedes aegypti. [PDF]

Commun Biol
Nevard K, Ang JXD, Anderson MAE, Gonzalez E, Shackleford L, Alphey L.   +5 more
europepmc   +1 more source

HER2 alterations in non-small cell lung cancer (NSCLC): from biology and testing to advances in treatment modalities

Ahmed Ismail, Aakash Desai, Yanis Boumber   +2 more
openalex   +1 more source

Telomerase activity in T-cells as a functional test for pathogenicity assessment of novel genetic variants in telomere biology disorders

Olivia Carlund, Anna Norberg, Pia Osterman, Ida Andersson, A Eriksson, Sofie Degerman, Magnus Hultdin   +6 more
openalex   +1 more source