Results 261 to 270 of about 17,620,834 (388)

A novel mutant allele of Mta3 in the mouse: genetic analysis of roles in immunity and androgen biology. [PDF]

G3 (Bethesda)
Chrysovergis K, Headley K, Harper KM, Moy SS, Grimm SA, Jefferson WN, Sifre MI, Mahapatra D, Rodriguez Y, Williams CJ, Wade PA.   +10 more
europepmc   +1 more source

Should the Mantel test be used in spatial analysis?

, 2015
P. Legendre, M. Fortin, D. Borcard
semanticscholar   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Quantifying HiPSC-CM structural organization at scale with deep learning-enhanced SarcGraph. [PDF]

PLoS Comput Biol
Mohammadzadeh S, Lejeune E.
europepmc   +1 more source

Advances in experimental medicine and biology

Advances in Experimental Medicine and Biology, 1996
Stephen J Thompson
semanticscholar   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Environmental enrichment as a therapeutic strategy against methamphetamine induces depressive behaviors in mice. [PDF]

PLoS One
Ismail H, Abdul Rafay S, Yaseen T, Khalid D, Bhatti MZ, Shahzad S, Shahzad S, Saleem S, Rahman A, Alotaibi MO, Turkistani A, Akram B, Batiha GE.   +12 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Association of estrogen receptor single nucleotide polymorphisms and perinatal depression. [PDF]

PLoS One
Björvang RD, Gumbo LF, Årdahl A, Lager S, Comasco E, Fransson E, Skalkidou A.   +6 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source