Results 41 to 50 of about 1,730,969 (264)

Integrated bioinformatics analysis reveals Netrin-1 as a key molecular link between Parkinson’s disease and heart failure

Frontiers in Aging Neuroscience
BackgroundParkinson’s disease (PD) patients face a higher risk of developing heart failure (HF). The objective of the study was to investigate the hub genes and potential mechanisms linking Parkinson’s disease (PD) to heart failure (HF) using multiple ...
Zhen Ni, Zhen Ni, Gaoge Wang, Yingyan Li, Yingyan Li, Huan Chen, Huan Chen, Hongwei Hou, Hongwei Hou, Qingyuan Hu, Qingyuan Hu   +10 more
doaj   +1 more source

Genetic Testing in the Diagnosis and Biology of Acute Leukemia

American Journal of Clinical Pathology, 2019
AbstractObjectivesThe 2017 Workshop of the Society for Hematopathology/European Association for Haematopathology examined the role of molecular genetics in the diagnosis and biology of acute leukemia.MethodsAcute leukemias were reviewed in two sessions: “Genetic Testing in Diagnosis of Acute Leukemias” (53 cases) and “Genetics Revealing the Biology of ...
Marian H, Harris, David R, Czuchlewski, Daniel A, Arber, Magdalena, Czader   +3 more
openaire   +2 more sources

An In-House Biology Placement Test Improves Success in Majors Introductory Biology [PDF]

The American Biology Teacher, 2017
Biology placement tests (BPTs) have most often been used to determine whether well-prepared students can “test out” of foundational coursework at the college or university level. However, not all high school students are equally prepared for majors-level introductory Biology.
Jesse P. Poole, Kristin L. Latham-Scott, Angela Z. Poole, Michael J. Baltzley, Sarah M. Boomer   +4 more
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Dynamic changes and early warning of peanuts aflatoxin B1 contamination in China in the context of climate change

npj Science of Food
Aflatoxin contamination is a major food safety concern and has a particularly negative impact on peanuts. Climate conditions are known to influence the natural occurrence of mycotoxins; however, the specific impacts of climate change on the prevalence of
Can Guo, Ya Zhao, Ao Liu, Du Wang, Xiao Wang, Li Yu, Fei Ma, Xuefang Wang, Mengxue Fang, Xiaoxia Ding, Antonio Francesco Logrieco, Peiwu Li, Liangxiao Zhang   +12 more
doaj   +1 more source

Evaluation of the antioxidant and anti-inflammatory efficacy of fermented Polygonatum sibiricum using zebrafish model

Biochemistry and Biophysics Reports
Background: Fermentation may enhance the skincare potential of the traditional Chinese medicine Polygonatum sibiricum (PS). This study aimed to evaluate the anti-oxidant and anti-inflammatory efficacy of fermented Polygonatum sibiricum (FPS) using ...
Wenjuan Cao, Chongxi Yang, Yilin Feng, Zhao Zhang, Yan Liu, Xiaodong Xu   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Metabolome and transcriptome analysis reveal the effect of methyl jasmonate on phytosterol biosynthesis in Brassica napus

Food Frontiers
Phytosterols are a group of nonpharmacological alternatives to prevent or control dyslipidemias and cardiovascular disease. Increasing the phytosterol content in rapeseed oil is important to enhance daily phytosterol intake.
Xueyan Wang, Min Liu, Ruinan Yang, Xiaobo Cui, Jie Liu, Yu Zhang, Yizhou He, Li Yu, Fei Ma, Xiong Zhang, Yuanyuan Zhang, Shengyi Liu, Peiwu Li, Liangxiao Zhang   +13 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source