Results 71 to 80 of about 1,766,427 (312)

PENGUJIAN VALIDITAS DAN PRAKTIKALITAS TES DISPOSISI BERPIKIR KRITIS DALAM BIOLOGI (TDBKB)

Jurnal Pendidikan Sains Universitas Muhammadiyah Semarang, 2019
Good instruments are not only seen from validity and reliability but can also be seen from practical values. The purpose of this study is to examine content validity and practicality of critical thinking disposition tests in biology.
Jayanti Syahfitri
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

On microRNA and the Need for Exploratory Experimentation in Post-Genomic Molecular Biology [PDF]

, 2007
This paper is devoted to an examination of the discovery, characterization, and analysis of the functions of microRNAs, which also serves as a vehicle for demonstrating the importance of exploratory experimentation in current (post-genomic) molecular ...
Burian, Richard M., Richard M. Burian
core  

Geographical Variation in Nutritional Components of Peanut: Evidence From Multi‐Region Production Areas

Food Frontiers
As an important oilseed and food material, the nutritional quality of peanut is influenced by not only the variety but also place of origin. However, research on the geographical impact remains scarce. In this study, nine peanut cultivars were planted at
Xueyan Wang, Xin Qi, Xiaofeng Yue, Mengxue Fang, Ao Liu, Fei Ma, Li Yu, Xuefang Wang, Du Wang, Peiwu Li, Liangxiao Zhang   +10 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A synonymous mutation of rs1137070 cause the mice Maoa gene transcription and translation to decrease

Frontiers in Molecular Neuroscience
The Monoamine Oxidase-A (MAOA) EcoRV polymorphism (rs1137070) is a unique synonymous mutation (c.1409 T > C) within the MAOA gene, which plays a crucial role in Maoa gene expression and function.
Kai Xin Li, Kai Xin Li, Kai Xin Li, Kai Xin Li, Kai Xin Li, Lei Fan, Lei Fan, Lei Fan, Lei Fan, Hongjuan Wang, Hongjuan Wang, Hongjuan Wang, Yushan Tian, Yushan Tian, Yushan Tian, Sen Zhang, Qingyuan Hu, Qingyuan Hu, Qingyuan Hu, Qingyuan Hu, Qingyuan Hu, Fanglin Liu, Fanglin Liu, Fanglin Liu, Fanglin Liu, Fanglin Liu, Huan Chen, Huan Chen, Huan Chen, Hongwei Hou, Hongwei Hou, Hongwei Hou   +31 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source