Results 171 to 180 of about 10,239,739 (303)

Synthetic Chromosomes in Yeast: A Platform for Understanding and Programming Eukaryotic Life. [PDF]

Microb Biotechnol
Lusk DT, Ehrenreich IM.
europepmc   +1 more source

Test Track; aerial view

Aerial view of the concrete tractor test track and east campus of the University of Nebraska-Lincoln looking toward the southeast.
Nebraska Tractor Test Laboratory
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Architectural good practices for reproducible benchmarking in protein machine learning. [PDF]

Front Bioinform
García-Vinuesa J, Fernández-Villegas D, Soto-García M, Cadet X, Davari MD, Cadet F, Asenjo JA, Uribe-Paredes R, Medina-Ortiz D.   +8 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Weak interface strong skeleton shrinkage resistant mix design for large cement stabilized base. [PDF]

iScience
Zhang N, Yan Z, Wang H, Tang D, Zheng G, Ma L, Zhang Y.   +6 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Study on prestress loss and safety performance of retard-bonded prestressed cast-in-place piles. [PDF]

PLoS One
Zhu W, Yang X, Zhou H, Yang J, Yao X.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Collected data on displacement and vibration tests of layered floor assembly constructed by using glued timber trusses. [PDF]

Data Brief
Hatsala A, Ilgın HE, Kinnunen N, Luukkainen JP, Malmstedt F, Pajunen S, Rinkinen K, Sormunen J.   +7 more
europepmc   +1 more source