Results 131 to 140 of about 1,035,244 (264)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Standard Automated Perimetry Before and After Extended Depth-of-Focus Intraocular Lens Implantation: Longitudinal Changes in Global Indices and Test Reliability. [PDF]

Clin Ophthalmol
Hida WT, da Silva MGB, Moscovici BK, Vilar C, Campos PTS, Gouvea L, Chow M, Tzelikis PFM, Chaves MAPD, Motta AFP, de Medeiros AL, Lake JC, Carricondo PC.   +12 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Dynamic Field Assessment of Hip Adductor Function Using a Smartphone-Based Copenhagen Test: Reliability and Concurrent Associations with Isometric Strength in Amateur Football Players. [PDF]

Sports (Basel)
Miralles-Iborra A, Urban T, De Los Ríos-Calonge J, Elvira JLL, Del Coso J, Tomás-Rodríguez MI, Juan-Recio C, Moreno-Pérez V.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Psychometric Properties of the Children's Auditory Perception Test: Reliability and Validity Analysis. [PDF]

Brain Behav
Icoz O, Isikhan SY, Yucel E.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Remote physical function testing in older adults: a mixed methods study exploring test reliability, feasibility, and perceptions of participants and assessors. [PDF]

PLoS One
Fyfe JJ, Sousa F, Watson-Mackie K, Jansons P, Scott D, Daly RM.   +5 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Novel Clinical Assessment of Visual, Vestibular, Somatosensory, and Autonomic Function: Establishing Test Re-Test Reliability in a Healthy Population. [PDF]

Percept Mot Skills
McGrath M, Waddington G, Bissett B, Fearon A, Witchalls J.   +4 more
europepmc   +1 more source