Results 81 to 90 of about 7,596,315 (208)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Validity evidence of the Social and Emotional Nationwide Assessment (SENNA 1.0) Inventory

Paidéia (Ribeirão Preto)
: Given the necessity of adequate instruments to measure socio-emotional skills, this study aimed to obtain validity evidence of the Social and Emotional Nationwide Assessment inventory (SENNA 1.0).
Gina Pancorbo, Jacob Arie Laros
doaj   +1 more source

Launay-Slade Hallucination Scale Revised - German version

Die deutsche Adaptation der LSHS dient dazu, mit 12 Fragen halluzinatorische Erfahrungen bei gesunden Erwachsenen im deutschen Sprachraum zu erfassen. Reliabilität: Cronbachs Alpha beträgt zwischen α = .83 und α = .87.
Lincoln, T. M.
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Test

Tes
Test
core   +1 more source

Evaluation of the Writing Skill in accordance with STANAG 6001: Digital Solutions

Philologia
The article examines the use of holistic and analytical assessments for English writing tests according to NATO STANAG 6001 standards. The author outlines the advantages and limitations of both methods, emphasizing the need for a review of digital tools ...
Rodica MOȘNEGUȚU
doaj   +1 more source

Investigating the Reliability of the Reading Module of the Iranian Ministry of Science, Research, and Technology’s English Proficiency Test [PDF]

Journal of English Language Teaching and Learning
As a national high-stakes test of English proficiency, MSRT needs further scrutiny of reliability. Thus, the present study aimed to investigate different sources of variation that may impact the MSRT test-takers’ reading comprehension.
Ali-Akbar Ariamanesh, Mohammad Hajimohammadi, Fereshteh Dehghan-Manshadi   +2 more
doaj   +1 more source

Caregiver-Child Socioemotional and Relationship Rating Scale - German version

Die klinischen Caregiver-Child Socioemotional and Relationship Rating Scales von McCall - deutsche Version (SIRS/CCSERRS) ist ein Beobachtungsinstrument zur globalen Einschätzungen von sieben Bereichen/Skalen (1. Interesse der Bezugsperson, 2.
Müller, J. M.
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source