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How phagocytic cells kill bacteria: Lessons from a professional killer
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
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Effect of terahertz irradiation on DNA damage repair in living cells
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
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Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
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1991
This paper introduces a process algebra which incorporates the auxiliary operators of ACP, [BK85], and is tailored towards algebraic verifications in the theory of testing equivalence. The process algebra we consider is essentially a version of ACP with the empty process in which the nondeterministic choice operators familiar from TCSP, [BHR84], and ...
Aceto, Luca, Ingolfsdottir, Anna
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This paper introduces a process algebra which incorporates the auxiliary operators of ACP, [BK85], and is tailored towards algebraic verifications in the theory of testing equivalence. The process algebra we consider is essentially a version of ACP with the empty process in which the nondeterministic choice operators familiar from TCSP, [BHR84], and ...
Aceto, Luca, Ingolfsdottir, Anna
openaire +2 more sources
International Journal of Technology Assessment in Health Care, 2005
Objectives:Prospect theory (PT) hypothesizes that people judge states relative to a reference point, usually assumed to be their current health. States better than the reference point are valued on a concave portion of the utility function; worse states are valued on a convex portion.
David, Feeny, Ken, Eng
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Objectives:Prospect theory (PT) hypothesizes that people judge states relative to a reference point, usually assumed to be their current health. States better than the reference point are valued on a concave portion of the utility function; worse states are valued on a convex portion.
David, Feeny, Ken, Eng
openaire +2 more sources
Program result-checking: a theory of testing meets a test of theory
Proceedings 35th Annual Symposium on Foundations of Computer Science, 2002We review the field of result-checking, discussing simple checkers and self-correctors. We argue that such checkers could profitably be incorporated in software as an aid to efficient debugging and reliable functionality. We consider how to modify traditional checking methodologies to make them more appropriate for use in real-time, real-number ...
Manuel Blum 0001, Hal Wasserman
openaire +1 more source

