Results 61 to 70 of about 955,170 (266)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Peters et al. Delusions Inventory - German version
Die deutsche Adaptation des PDI, PDI-G, als Kurz- (k = 21 Items) und Langfassung (k = 40 Items) erfasst auf drei Dimensionen (Besorgnis, Zeitliche Beschäftigung, Überzeugungsstärke) subklinischen Wahn bei Erwachsenen.
Lincoln, T. M.
core +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
The Revised UCLA Loneliness Scale (Russell, D., Peplau, L. A. & Cutrona, C., 1980) - Cologne version
Die KSE ist eine Adaptation des amerikanischen Originals und misst mit 20 Items Einsamkeit. Reliabilität: Die interne Konsistenz nach Cronbachs Alpha und die Split-half-Reliabilität lagen bei .88, die Stabilität nach einem 3-Monatsintervall bei rtt = .72.
Lamm, H., Stephan, E., Fäth, M.
core +1 more source
Verfahrensdokumentation für ÜBER: Test für Erziehungsverhalten zum "Überbehüten"
, 1999 Das Verfahren erfasst die Stärke und die Erscheinungsformen der Problematik "Überbehüten" im elterlichen Erziehungsverhalten. Als Grundlage dienten die Overprotection-Skala des Parental Bonding Instruments (PBI) von Parker et al.
Böhm, B.
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Stress and Coping Inventory (2nd, revised and standardized edition)
Die Revision des Stress- und Coping-Inventars (SCI) erfasst mit insgesamt sieben Skalen und 45 Items psychische Stressbelastung, Stresssymptome und Stressbewältigungsstrategien.
Satow, L.
core +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source